Evidence map›Paper›PMID 31337113›Full record

ArticleBiomolecules2019

Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor.

Yuxi Miao, Guanzhu Chen, Xinping Xi, Chengbang Ma, Lei Wang, James F Burrows, Jinao Duan, Mei Zhou, Tianbao Chen

Abstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Digestive Inflammation: Role of Proteolytic Dysregulation.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxi MiaoNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.
Guanzhu ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.
Xinping XiNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.
Chengbang MaNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK. c.ma@qub.ac.uk.
Lei WangNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.ORCID 0000-0002-8811-8489
James F BurrowsNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.
Jinao DuanJiangsu Key Laboratory for Traditional Chinese Medicine (TCM) Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046, China.
Mei ZhouNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK. m.zhou@qub.ac.uk.ORCID 0000-0003-2576-0252
Tianbao ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.ORCID 0000-0001-8011-9260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anuran amphibian skin secretions are a rich source of peptides, many of which represent novel protease inhibitors and can potentially act as a source for protease inhibitor drug discovery. In this study, a novel bioactive Bowman-Birk type inhibitory hexadecapeptide of the Ranacyclin family from the defensive skin secretion of the Fukien gold-striped pond frog,

Indexed as

Antifungal AgentsDrug DesignGene LibraryProtease InhibitorsAntifungal AgentsProtease Inhibitorsamphibian Bowman-Birk inhibitorantifungaldrug designmolecular cloningprotease inhibitorTat peptide

Identifiers

PMID31337113
PMCPMC6681222

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.