Evidence map›Paper›PMID 31337023›Full record

SynthesisNutrients2019

Nutritional Deficiencies in Children with Celiac Disease Resulting from a Gluten-Free Diet: A Systematic Review.

Giovanni Di Nardo, Maria Pia Villa, Laura Conti, Giusy Ranucci, Claudia Pacchiarotti, Luigi Principessa, Umberto Raucci, Pasquale Parisi

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 5 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 147 citations in OpenAlex.

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  16. Article
  17. Long-term laboratory follow-up is essential in pediatric patients with celiac.Journal of pediatric gastroenterology and nutrition · 2025
    Article
  18. Celiac Disease: Beyond Diet and Food Awareness.Foods (Basel, Switzerland) · 2025
    Review
  19. Article
  20. Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2025
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Giovanni Di NardoChair of Pediatrics, School of Medicine and Psychology, NESMOS Department, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.ORCID 0000-0002-9026-7758
Maria Pia VillaChair of Pediatrics, School of Medicine and Psychology, NESMOS Department, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.
Laura ContiDepartment of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.
Giusy RanucciPediatric Unit, AORN Santobono-Pausilipon, 80129 Naples, Italy.
Claudia PacchiarottiChair of Pediatrics, School of Medicine and Psychology, NESMOS Department, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.
Luigi PrincipessaChair of Pediatrics, School of Medicine and Psychology, NESMOS Department, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.
Umberto RaucciPediatric Emergency Department, Bambino Gesù Children Hospital, IRCCS, 00165 Rome, Italy.
Pasquale ParisiChair of Pediatrics, School of Medicine and Psychology, NESMOS Department, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy. pasquale.parisi@uniroma1.it.ORCID 0000-0001-9042-8120
Sapienza University of Rome · ITBambino Gesù Children's Hospital · ITSantobono Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA strictly gluten-free diet (GFD) is the basis for managing celiac disease (CD). Numerous studies have reported nutritional deficiencies/imbalances ascribable to a GFD. The aim of this review is to describe nutritional deficiencies observed in children with celiac disease on a GFD, to discuss the clinical consequences related to these nutritional imbalances, and to identify strategies that may be adopted to treat them.

methodsWe reviewed the MEDLINE and EMBASE databases between January 1998 and January 2019.

resultsChildren are, regardless of whether they are on a gluten-free diet or not, at risk of consuming too much fat and insufficient fiber, iron, vitamin D, and calcium. These imbalances may be exacerbated when children are on a gluten-free diet. In particular, the intake of folate, magnesium, zinc, and foods with a high glycemic index in children with CD who are on a GFD is significantly altered.

conclusionsTherapeutic protocols should include nutritional education to help teach subjects affected by disorders such as CD the importance of labels, the choice of foods, and the combination of macro- and micronutrients. Children with CD on a GFD should be encouraged to rotate pseudo-cereals, consume gluten-free commercial products that have been fortified or enriched, and use foods that are local and naturally gluten-free.

Indexed as

Celiac DiseaseChildChild Nutritional Physiological PhenomenaChild Nutrition DisordersDiet, Gluten-FreeHumansceliac diseasegluten-free dietgluten-free productsnutritional deficiencies

Identifiers

PMID31337023
PMCPMC6683263
OpenAlexW2962034259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.