Evidence map›Paper›PMID 31336999›Full record

ReviewInternational journal of molecular sciences2019

Long Non-coding RNAs as Important Biomarkers in Laryngeal Cancer and Other Head and Neck Tumours.

Alessia Maria Cossu, Laura Mosca, Silvia Zappavigna, Gabriella Misso, Marco Bocchetti, Federica De Micco, Lucio Quagliuolo, Marina Porcelli, Michele Caraglia, Mariarosaria Boccellino

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 94 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. [The study on effect of EIF3B in laryngeal carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  7. Article
  8. Review
  9. Epigenetic silencing ofOncology reports · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. MiR-449a antagonizes EMT through IL-6-mediatedMolecular therapy. Nucleic acids · 2024
    Article
  18. TiOAnalytical and bioanalytical chemistry · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alessia Maria CossuBiogem scarl, Institute of Genetic Research, Laboratory of Molecular and Precision Oncology, 83031 Ariano Irpino (AV), Italy.
Laura MoscaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Silvia ZappavignaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Gabriella MissoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Marco BocchettiDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.ORCID 0000-0002-2143-6669
Federica De MiccoBiogem scarl, Institute of Genetic Research, Laboratory of Molecular and Precision Oncology, 83031 Ariano Irpino (AV), Italy.
Lucio QuagliuoloDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Marina PorcelliDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Michele CaragliaBiogem scarl, Institute of Genetic Research, Laboratory of Molecular and Precision Oncology, 83031 Ariano Irpino (AV), Italy. michele.caraglia@unicampania.it.
Mariarosaria BoccellinoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITBiogem · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck carcinoma (HNC) is a heterogeneous disease encompassing a variety of tumors according to the origin. Laryngeal cancer (LC) represents one of the most frequent tumors in the head and neck region. Despite clinical studies and advance in treatment, satisfactory curative strategy has not yet been reached. Therefore, there is an urgent need for the identification of specific molecular signatures that better predict the clinical outcomes and markers that serve as suitable therapeutic targets. Long non-coding RNAs (lncRNA) are reported as important regulators of gene expression and represent an innovative pharmacological application as molecular biomarkers in cancer. The purpose of this review is to discuss the most relevant epigenetic and histological prognostic biomarkers in HNC, with particular focus on LC. We summarize the emerging roles of long non-coding RNAs in HNC and LC development and their possible use in early diagnosis.

Indexed as

Biomarkers, TumorAnimalsCell Line, TumorComputational BiologyGene Expression ProfilingGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansLaryngeal NeoplasmsMolecular Sequence AnnotationPrognosisRNA InterferenceRNA, Long NoncodingBiomarkers, TumorRNA, Long Noncodinghead and neck cancer (HNC)head and neck squamous-cell carcinoma (HNSCC)laryngeal cancer (LC)laryngeal squamous cell carcinoma (LSCC)long ncRNA (lncRNA)prognostic biomarker

Identifiers

PMID31336999
PMCPMC6678449
OpenAlexW2961086284

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.