ArticleMolecules (Basel, Switzerland)2019
Velutin, an Aglycone Extracted from Korean Mistletoe, with Improved Inhibitory Activity against Melanin Biosynthesis.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Process Optimization and Flavor Analysis ofFoods (Basel, Switzerland) · 2026Article
- Velutin Inhibits IL-1β-Induced Nucleus Pulposus Inflammatory and Extracellular Matrix Degradation Attenuating Mouse Intervertebral Disc Degeneration via the NF-κB and MAPK Pathways.Mediators of inflammation · 2025Article
- Genus Stachys-Phytochemistry, Traditional Medicinal Uses, and Future Perspectives.Molecules (Basel, Switzerland) · 2024Review
- Phytochemistry and Cytotoxic Activity ofACS omega · 2023Article
- Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders.International journal of molecular sciences · 2022Review
- Traditional Use, Phytochemical Profiles and Pharmacological Properties ofMolecules (Basel, Switzerland) · 2022Review
- Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.BMC complementary medicine and therapies · 2022Article
- Dual protective role of velutin against articular cartilage degeneration and subchondral bone lossFrontiers in endocrinology · 2022Article
- Characterization of Phenethyl Cinnamamide Compounds from Hemp Seed and Determination of Their Melanogenesis Inhibitory Activity.ACS omega · 2021Article
- Anti-Melanogenic Properties of Velutin and Its Analogs.Molecules (Basel, Switzerland) · 2021Article
- Characterization of Caffeoylquinic Acids fromACS omega · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The abnormal regulation of melanin synthesis leads to a wide range of pigmentary disorders. Although various melanin biosynthesis inhibitors have been developed, their efficacy and long-term safety needs to be further improved, and thus the goal of this study is to develop promising natural compound inhibitors of melanin biosynthesis. Here, we obtained aglycone flavonoid extract through the microwave-assisted hydrolysis of glycoside extract from Korean mistletoe in acidic condition. The aglycone extract inhibited tyrosinase activity more efficiently with better antioxidant activity than glycoside extract in vitro. The microwave-assisted aglycone extract of mistletoe was further analyzed for in vivo activity, and the results showed the aglycone extract inhibited both early melanocyte development and melanin synthesis more efficiently in zebrafish embryo in a dose-dependent manner. Our in vivo toxicity assay quantitatively measured cell death in zebrafish embryos and showed that the microwave-assisted aglycone extract of mistletoe had no significant effect on cell death (
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