Evidence map›Paper›PMID 31336927›Full record

ArticleJournal of clinical medicine2019

Progenitor Cells Derived from Drain Waste Product of Open-Heart Surgery in Children.

Tak-Wah Wong, Chung-Dann Kan, Wen-Tai Chiu, Kin Lam Fok, Ye Chun Ruan, Xiaohua Jiang, Junjiang Chen, Chiu-Ching Kao, I-Yu Chen, Hui-Chun Lin and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tak-Wah WongDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.ORCID 0000-0002-0131-7339
Chung-Dann KanDepartment of Surgery, Institute of Cardiovascular Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Wen-Tai ChiuDepartment of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0003-0310-0675
Kin Lam FokEpithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong.
Ye Chun RuanEpithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong.
Xiaohua JiangEpithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong.
Junjiang ChenEpithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong.
Chiu-Ching KaoDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
I-Yu ChenDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Hui-Chun LinDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Chia-Hsuan ChouDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Chou-Wen LinBiomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Liuo-Jia, Tainan 734, Taiwan.
Chun-Keung YuInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Stephanie TsaoDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Yi-Ping LeeInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Hsiao Chang ChanEpithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong.
Jieh-Neng WangDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan. jiehneng@mail.ncku.edu.tw.

Funding

Center of Applied Nanomedicine, National Cheng Kung University from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan to T.W.W.Chinese University of Hong Kong 466710 to X.J.Focused Investment Scheme and Li Ka Shing Institute of Health Science of the Chinese University of Hong Kong to H.C.C.Ministry of Science and Technology, Taiwan 1002627E033001, 1072321B006008Ministry of Science and Technology, Taiwan 101-2314-B-6-031, 102-2314-B-006-018, 103-2314-B-006-077Ministry of Science and Technology, Taiwan 105-2628-B-006-003-MY3 to W.T.C.Ministry of Science and Technology, Taiwan 972314B006018MY2, 106-2218-E-006-020National Cheng Kung University B106-K028, B107-K048National Cheng Kung University Hospital 10506007 to J.N.W.National Cheng Kung University Hospital 10703019National Cheng Kung University Hospital 10705004 to C.D.K.
6 · The paper itself

Abstract

Human cardiac progenitor cells isolated from the same host may have advantages over other sources of stem cells. The aim of this study is to establish a new source of human progenitor cells collected from a waste product, pericardiac effusion fluid, after open-heart surgery in children with congenital heart diseases. The fluid was collected every 24 h for 2 days after surgery in 37 children. Mononuclear cells were isolated and expanded in vitro. These pericardial effusion-derived progenitor cells (PEPCs) exhibiting cardiogenic lineage markers, were highly proliferative and enhanced angiogenesis in vitro. Three weeks after stem cell transplantation into the ischemic heart in mice, cardiac ejection fraction was improved significantly without detectable progenitor cells. Gene expression profiles of the repaired hearts revealed activation of several known repair mechanisms including paracrine effects, cell migration, and angiogenesis. These progenitor cells may have the potential for heart regeneration.

Indexed as

cardiac surgerycongenital heart diseaseopen heartprogenitor cellsregenerationstem cells

Identifiers

PMID31336927
PMCPMC6678880

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.