Evidence map›Paper›PMID 31336900›Full record

ArticleMolecules (Basel, Switzerland)2019

Anticancer Function and ROS-Mediated Multi-Targeting Anticancer Mechanisms of Copper (II) 2-hydroxy-1-naphthaldehyde Complexes.

Muhammad Hamid Khan, Meiling Cai, Jungang Deng, Ping Yu, Hong Liang, Feng Yang

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

  1. Cobalt complexes in biology and medicine: enzymatic functions, pharmacological applications, and health challenges.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A selective CuScientific reports · 2021
    Article
  11. Article
  12. Article
  13. Structure-Based Design of Biologically Active Compounds.Molecules (Basel, Switzerland) · 2020
    Article
  14. Copper Coordination Compounds as Biologically Active Agents.International journal of molecular sciences · 2020
    Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Muhammad Hamid KhanState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, Guangxi, China.ORCID 0000-0002-4072-1633
Meiling CaiState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, Guangxi, China.
Jungang DengState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, Guangxi, China.
Ping YuState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, Guangxi, China.
Hong LiangState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, Guangxi, China. hliang@mailbox.gxnu.edu.cn.
Feng YangState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, Guangxi, China. fyang@mailbox.gxnu.edu.cn.
Guangxi Normal University · CN

Funding

National Natural Science Foundation of China 21431001, 31460232Natural Science Foundation of Guangxi 2017GXNSFEA198002, AD17129007
6 · The paper itself

Abstract

Multi-targeting of oncoproteins by a single molecule represents an effectual, rational, and an alternative approach to target therapy. We carried out a systematic study to reveal the mechanisms of action of newly synthesized Cu

Indexed as

Antineoplastic AgentsAutophagyBiomarkersCell Line, TumorCopperDose-Response Relationship, DrugDrug StabilityEndoplasmic Reticulum StressHumansMolecular StructureNaphthalenesReactive Oxygen SpeciesSignal TransductionSolubilityStructure-Activity Relationship2-hydroxy-1-naphthaldehydeAntineoplastic AgentsBiomarkersCopperNaphthalenesReactive Oxygen Species2-hydroxy-1-naphthaldehydeanticancer mechanismCu(II) complexcytotoxicity

Identifiers

PMID31336900
PMCPMC6680819
OpenAlexW2956367190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.