ArticleGenes2019
MODIMA, a Method for Multivariate Omnibus Distance Mediation Analysis, Allows for Integration of Multivariate Exposure-Mediator-Response Relationships.
Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Pollutant biodegradation profile mediated by multi-trophic microbial dynamics in rivers.ISME communications · 2026Article
- Microbiome mediation analysis: methods, assumptions, and practical considerations.Frontiers in cellular and infection microbiology · 2026Review
- Exploring the role of microbiome in cystic fibrosis clinical outcomes through a mediation analysis.mSystems · 2025Article
- Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease.Microbiome · 2025Article
- Chemical pollution drives taxonomic and functional shifts in marine sediment microbiome, influencing benthic metazoans.ISME communications · 2025Article
- Feeding intolerance after pediatric cardiac surgery is associated with dysbiosis, barrier dysfunction, and reduced short-chain fatty acids.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Statistical and computational methods for integrating microbiome, host genomics, and metabolomics data.eLife · 2024Review
- Diet-Microbiome Interactions Influence Lung Function in Chronic Obstructive Pulmonary Disease.Frontiers in microbiomes · 2024Article
- Piglet cardiopulmonary bypass induces intestinal dysbiosis and barrier dysfunction associated with systemic inflammation.Disease models & mechanisms · 2023Article
- PhyloMed: a phylogeny-based test of mediation effect in microbiome.Genome biology · 2023Article
- Exclusive breast-feeding, the early-life microbiome and immune response, and common childhood respiratory illnesses.The Journal of allergy and clinical immunology · 2022Article
- A new approach to testing mediation of the microbiome at both the community and individual taxon levels.Bioinformatics (Oxford, England) · 2022Article
- Article
- Adaptive and powerful microbiome multivariate association analysis via feature selection.NAR genomics and bioinformatics · 2022Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Many important exposure-response relationships, such as diet and weight, can be influenced by intermediates, such as the gut microbiome. Understanding the role of these intermediates, the mediators, is important in refining cause-effect theories and discovering additional medical interventions (e.g., probiotics, prebiotics). Mediation analysis has been at the heart of behavioral health research, rapidly gaining popularity with the biomedical sciences in the last decade. A specific analytic challenge is being able to incorporate an entire 'omics assay as a mediator. To address this challenge, we propose a hypothesis testing framework for multivariate omnibus distance mediation analysis (MODIMA). We use the power of energy statistics, such as partial distance correlation, to allow for analysis of multivariate exposure-mediator-response triples. Our simulation results demonstrate the favorable statistical properties of our approach relative to the available alternatives. Finally, we demonstrate the application of the proposed methods in two previously published microbiome datasets. Our framework adds a new tool to the toolbox of approaches to the integration of 'omics big data.
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