Evidence map›Paper›PMID 31336760›Full record

ArticleMetabolites2019

Salivary Metabolome and Soccer Match: Challenges for Understanding Exercise induced Changes.

Erica Pitti, Greta Petrella, Sara Di Marino, Vincenzo Summa, Marco Perrone, Stefano D'Ottavio, Andrea Bernardini, Daniel Oscar Cicero

Abstract read
In one paragraph

Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Article
  6. Energy production pathways of female soccer players during championships: a metabolomics approach.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  7. Article
  8. Omics Sciences in Regular Physical Activity.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erica PittiDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy.
Greta PetrellaDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy.
Sara Di MarinoIRBM S.p.A., 00071 Pomezia, Italy.
Vincenzo SummaIRBM S.p.A., 00071 Pomezia, Italy.
Marco PerroneDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133 Rome, Italy.
Stefano D'OttavioDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Andrea BernardiniDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133 Rome, Italy.
Daniel Oscar CiceroDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy. cicero@scienze.uniroma2.it.ORCID 0000-0001-5012-1714

Funding

Collezione Nazionale di Composti Chimici e Centro Screening (CNCCS) Consortium Project B, Sp 2, WP2, 2018
6 · The paper itself

Abstract

Saliva samples of seventeen soccer players were analyzed by nuclear magnetic resonance before and after an official match. Two different ways of normalizing data are discussed, using total proteins and total metabolite concentrations. Changes in markers related to energy, hydration status, amino acids and other compounds were found. The limits and advantages of using saliva to define the systemic responses to exercise are examined, both in terms of data normalization and interpretation, and the time that the effect lasts in this biofluid, which is shorter to that commonly observed in blood. The heterogeneous nature and different timing of the exercise developed by players also plays an important role in the metabolic changes that can be measured. Our work focuses mainly on three different aspects: The effect that time sampling has on the observed effect, the type of normalization that is necessary to perform in order to cope with changes in water content, and the metabolic response that can be observed using saliva.

Indexed as

energy metabolismexercisehydration statusmetabolomicsNMRsalivasport metabolomics

Identifiers

PMID31336760
PMCPMC6680540

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.