Evidence map›Paper›PMID 31336733›Full record

ArticleCells2019

A Novel Assay for Profiling GBM Cancer Model Heterogeneity and Drug Screening.

Christian T Stackhouse, James R Rowland, Rachael S Shevin, Raj Singh, G Yancey Gillespie, Christopher D Willey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Christian T StackhouseDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-6660-1963
James R RowlandDepartment of Physics, Ohio State University, Columbus, OH 43210, USA.
Rachael S ShevinCenter for Clinical and Translational Science, The University of Alabama at Birmingham, AL 35294, USA.
Raj SinghInstitute of Regenerative Medicine, LifeNet Health, Virginia Beach, VA 23453, USA.ORCID 0000-0001-5170-9325
G Yancey GillespieDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA. gygillespie@uabmc.edu.
Christopher D WilleyDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. cwilley@uabmc.edu.ORCID 0000-0001-9953-0279
University of Alabama at Birmingham · USLifenet Health · USThe Ohio State University · US

Funding

Viral and molecular chemotherapy of malignant CNS tumorsP50CA097247 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GILLESPIE, G. YANCEY · 2002 to 2009
$13.5M
Glioblastoma tumor microenvironmental influence on acquired and inherent cancer therapy resistance.U01CA223976 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, JAKE YUE, CUI, XIANGQIN · 2018 to 2022
$4.8M
CONTEMPORARY THERAPEUTICS FOR ANAPLASTIC GLIOMASP20CA151129 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GILLESPIE, G. YANCEY · 2011 to 2013
$2.3M
3D-Microtumor_GBM Xenoline Proband Modeling of Kinome-Directed TherapyR21CA185712 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLEY, CHRISTOPHER D · 2014 to 2015
$363k
NCI NIH HHS P20 CA151129NCI NIH HHS P50 CA097247NCI NIH HHS R21 CA185712NCI NIH HHS U01 CA223976
6 · The paper itself

Abstract

Accurate patient-derived models of cancer are needed for profiling the disease and for testing therapeutics. These models must not only be accurate, but also suitable for high-throughput screening and analysis. Here we compare two derivative cancer models, microtumors and spheroids, to the gold standard model of patient-derived orthotopic xenografts (PDX) in

Indexed as

AnimalsBrain NeoplasmsCell Line, TumorDisease Models, AnimalDrug Evaluation, PreclinicalEarly Detection of CancerGene Expression ProfilingGlioblastomaHumansMiceMice, NudeXenograft Model Antitumor Assaysdrug screeningGlioblastoma multiforme (GBM)heterogeneitymicrotumorsNanoStringpatient-derived xenografts (PDX)spheroids

Identifiers

PMID31336733
PMCPMC6678976
OpenAlexW2961014744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.