Evidence map›Paper›PMID 31336679›Full record

ArticleCancers2019

So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020.

Manuel Rodrigues, Leanne de Koning, Sarah E Coupland, Aart G Jochemsen, Richard Marais, Marc-Henri Stern, André Valente, Raymond Barnhill, Nathalie Cassoux, Andrew Evans and 8 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. The multiple roles of autophagy in uveal melanoma and the microenvironment.Journal of cancer research and clinical oncology · 2024
    Pooled it
  2. The latestExpert opinion on drug discovery · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Pathological and Molecular Diagnosis of Uveal Melanoma.Diagnostics (Basel, Switzerland) · 2024
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Intrinsic disorder may drive the interaction of PROS1 and MERTK in uveal melanoma.International journal of biological macromolecules · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 5 countries.

Manuel RodriguesDepartment of Medical Oncology and INSERM U830, Institut Curie, PSL Research University, 75005 Paris, France. manuel.rodrigues@curie.fr.
Leanne de KoningTranslational Research Department, Institut Curie, PSL Research University, 75005 Paris, France.
Sarah E CouplandDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.
Aart G JochemsenDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Richard MaraisMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester M13 9PL, UK.
Marc-Henri SternDepartment of Genetics, Institut Curie, PSL Research University, 75005 Paris, France.
André ValenteChampalimaud Foundation, 1400-038 Lisbon, Portugal.
Raymond BarnhillDepartment of Biopathology, Institut Curie, PSL Research University, 75005 Paris, France.
Nathalie CassouxDepartment of Ocular Oncology, Institut Curie, PSL Research University, 75005 Paris, France.
Andrew EvansMelanoma Patient Network Europe, 75597 Uppsala, Sweden.
Iain GallowayMelanoma Patient Network Europe, 75597 Uppsala, Sweden.
Martine J JagerDepartment of Ophthalmology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Ellen KapiteijnDepartment of Medical Oncology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Bozena Romanowska-DixonDepartment of Ophthalmology and Ocular Oncology, Jagiellonian University Medical 31007 Krakow, Poland.
Bettina RyllMelanoma Patient Network Europe, 75597 Uppsala, Sweden.
Sergio Roman-RomanTranslational Research Department, Institut Curie, PSL Research University, 75005 Paris, France.
Sophie Piperno-NeumannDepartment of Medical Oncology, Institut Curie, PSL Research University, 75005 Paris, France.
UM Cure 2020 ConsortiumDepartment of Medical Oncology and INSERM U830, Institut Curie, PSL Research University, 75005 Paris, France.
Université Paris Sciences et Lettres · FRLeiden University Medical Center · NLChampalimaud Foundation · PTInserm · FRJagiellonian University · PLUniversity of Liverpool · GBUniversity of Manchester · GB

Funding

Cancer Research UK 17240Cancer Research UK 19279Cancer Research UK 22902
6 · The paper itself

Abstract

Despite much progress in our understanding of uveal melanoma (UM) over the past decades, this rare tumour is still often misclassified. Although UM, like other melanomas, is very probably derived from melanocytes, it is drastically different from cutaneous melanoma and most other melanoma subtypes in terms of epidemiology, aetiology, biology and clinical features, including an intriguing metastatic hepatotropism. UM carries distinctive prognostic chromosome alterations, somatic mutations and gene expression profiles, allowing an active tailored surveillance strategy and dedicated adjuvant clinical trials. There is no standard systemic treatment for disseminated UM at present. In contrast to cutaneous melanoma, UMs are not

Indexed as

conjunctival melanomacutaneous melanomahealth policymucosal melanomauveal melanoma

Identifiers

PMID31336679
PMCPMC6678543
OpenAlexW2963803700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.