ArticleJournal of clinical medicine2019
Could Neutrophil-to-Lymphocyte Ratio (NLR) Serve as a Potential Marker for Delirium Prediction in Patients with Acute Ischemic Stroke? A Prospective Observational Study.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03944694 (White Cell Ratios as Markers of Delirium and Outcome in Acute Ischemic Stroke. DELirium in Acute Ischemic Stroke [DELIAS]), which is not on this map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
White Cell Ratios as Markers of Delirium and Outcome in Acute Ischemic Stroke. DELirium in Acute Ischemic Stroke [DELIAS]
Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Role of Peripheral Inflammation in Delirium.Brain and behavior · 2025Pooled it
- The associations of post-stroke delirium with outcomes: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as prognostic predictors for delirium in critically ill patients: a systematic review and meta-analysis.BMC anesthesiology · 2023Pooled it
- Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Pooled it
- Prediction models for post-stroke delirium: a systematic review with an exploratory meta-analysis of predictors.Frontiers in neurologyPooled it
- Expression of HO1 and PER2 can predict the incidence of delirium in trauma patients with concomitant brain injury.Scientific reports · 2021Trial
- Age-stratified immune characteristics in central nervous system tuberculosis patients: a comparative T lymphocyte subset analysis within a cohort of 862 extrapulmonary tuberculosis patients.BMC infectious diseases · 2025Article
- Clinical prediction rules for cognitive outcomes post-stroke: an updated systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Development and validation of a delirium prediction model for hospitalized older medical patients: a prospective cohort study.BMC geriatrics · 2025Article
- Neutrophil-to-lymphocyte ratio and systemic inflammation response index as biomarkers for the clinical outcomes of intracerebral hemorrhagic stroke patients: a prospective cohort study.Frontiers in neurology · 2025Article
- Can Neutrophil-to-Lymphocyte Ratio, Platelet Volume, and Platelet Distribution Width Be Used as Indicators of Delirium?Journal of clinical medicine · 2024Article
- How to predict postoperative delirium in geriatric patients with hip fracture as soon as possible? A retrospective study.BMC surgery · 2024Article
- Effects of peripheral blood cells on ischemic stroke: Greater immune response or systemic inflammation?Heliyon · 2024Review
- Review
- Association of the Neutrophil-to-Lymphocyte Ratio with 90-Day Functional Outcomes in Patients with Acute Ischemic Stroke.Brain sciences · 2024Article
- Neutrophil Heterogeneity and its Roles in the Inflammatory Network after Ischemic Stroke.Current neuropharmacology · 2023Article
- Carotid Plaque Features and Inflammatory Biomarkers as Predictors of Restenosis and Mortality Following Carotid Endarterectomy.International journal of environmental research and public health · 2022Article
- The Role of Vascular Risk Factors in Post-Stroke Delirium: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Prolonged increased neutrophil-to-lymphocyte ratio is associated with mortality after successful revascularization for treatment of acute ischemic stroke.BMC neurology · 2022Article
- Automated machine learning-based model predicts postoperative delirium using readily extractable perioperative collected electronic data.CNS neuroscience & therapeutics · 2022Observational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delirium is an acute brain disorder that commonly occurs in patients with acute ischemic stroke (AIS). Pathomechanism of delirium is related to the neuroinflammatory process and oxidative stress. Search for readily available diagnostic marker that will aid clinicians in early identification of delirium is ongoing. The aim of this study was to investigate whether neutrophil-to-lymphocyte ratio (NLR) could serve as a potential marker for delirium prediction in patients with AIS and to find an easy diagnostic tool using laboratory and clinical parameters to predict delirium. Prospective observational study (NCT03944694) included patients with AIS admitted to the neurology department of a district general hospital. All patients were screened for delirium using CAM-ICU (Confusion Assessment Method for Intensive Care Unit). Demographic and medical history data and admission lab results, including differential white blood cell analysis, were collected from all patients. We included 1001 patients in the final analysis. The mean age of the sample was 71 years, and 52% of patients were males. The incidence of early-onset delirium was 17.2%. The NLR was elevated in delirious patients (6.39 ± 8.60 vs. 4.61 ± 5.61,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.