ArticlePharmaceutics2019
Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery.
Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 64 citations in OpenAlex.
- Synthesis, characterization and in vitro release kinetics of methotrexate from oxidized fenugreek gum/chitosan-catechin bionanocomposite hydrogel matrix.Discover nano · 2026Article
- Oxygen Permeable Dextran Nanogels as a Hemoglobin-Based Oxygen Carrier.Biomaterials research · 2026Article
- Periodate oxidation of tragacanth gum and evaluation of physicochemical and biological properties of oxidized tragacanth gum.Scientific reports · 2025Article
- Unveiling the Future: Opportunities in Long-Acting Injectable Drug Development for Veterinary Care.Pharmaceutics · 2025Review
- Review
- Review
- Green Chemistry Principles for Nano- and Micro-Sized Hydrogel Synthesis.Molecules (Basel, Switzerland) · 2023Review
- Plant Polysaccharides in Engineered Pharmaceutical Gels.Bioengineering (Basel, Switzerland) · 2022Review
- Optimization of the Synthesis of Natural Polymeric Nanoparticles of Inulin Loaded with Quercetin: Characterization and Cytotoxicity Effect.Pharmaceutics · 2022Article
- Inulin and Its Application in Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Surfactants: physicochemical interactions with biological macromolecules.Biotechnology letters · 2021Review
- pH-Responsive "Smart" Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds.Antibiotics (Basel, Switzerland) · 2021Article
- Article
- Special Issue on Designing Hydrogels for Controlled Drug Delivery: Guest Editors' Introduction.Pharmaceutics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inulin-based hydrogels are useful carriers for the delivery of drugs in the colon-targeted system and in other biomedical applications. In this project, inulin hydrogels were fabricated by crosslinking oxidized inulin with adipic acid dihydrazide (AAD) without the use of a catalyst or initiator. The physicochemical properties of the obtained hydrogels were further characterized using different techniques, such as swelling experiments, in vitro drug release, degradation, and biocompatibility tests. The crosslinking was confirmed with Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). In vitro releases of 5-fluorouracil (5FU) from the various inulin hydrogels was enhanced in acidic conditions (pH 5) compared with physiological pH (pH 7.4). In addition, blank gels did not show any appreciable cytotoxicity, whereas 5FU-loaded hydrogels demonstrated efficacy against HCT116 colon cancer cells, which further confirms the potential use of these delivery platforms for direct targeting of 5-FU to the colon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.