ReviewNutrients2019
The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 4 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.BMC women's health · 2026Pooled it
- Efficacy of L-arginine and Pycnogenol ® in the treatment of male erectile dysfunction: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Effect of l-Arginine Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-analysis of Randomized Clinical Trials.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Prediction of pregnancy-related hypertensive disorders using metabolomics: a systematic review.BMJ open · 2022Pooled it
- No QTcF Prolongation with Sepiapterin: Results From a Thorough QT Study in Healthy Subjects at Therapeutic and Supratherapeutic Doses.Journal of clinical pharmacology · 2026Trial
- Trial
- THE EFFECT OF A SINGLE ORAL DOSE OF L-ARGININE ON QUADRICEPS STRENGTH IN SMOKERS AND NON-SMOKERS: A NON-RANDOMIZED CLINICAL TRIAL.Acta clinica Croatica · 2024Trial
- Effects of branched chain amino acids, l-citrulline, and alpha-glycerylphosphorylcholine supplementation on exercise performance in trained cyclists: a randomized crossover trial.Journal of the International Society of Sports Nutrition · 2023Trial
- Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.Nutrients · 2022Trial
- New perspectives for investigating muscular perfusion response after dietary supplement intake: an exploratory, randomized, double-blind, placebo-controlled crossover trial in healthy young athletes using contrast-enhanced ultrasound (CEUS).Journal of the International Society of Sports Nutrition · 2022Trial
- Daily 100% watermelon juice consumption and vascular function among postmenopausal women: A randomized controlled trial.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021Trial
- Article
- A Genomic Investigation into the Probiotic Attributes Among Members of the Lactobacillaceae family.Current microbiology · 2025Article
- Polyphenolic Compounds in the Prevention and Treatment of Hypertension: A Review.International journal of molecular sciences · 2025Review
- Use of melatonin plus citrulline or arginine to mitigate ergot alkaloid-induced vasoconstriction in sheep.Animal feed science and technology · 2025Article
- DietaryAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- The effects of L-citrulline supplementation on cerebrovascular function during sprint interval training in taekwondo athletes.Journal of exercise science and fitness · 2025Article
- Recent Advances and Perspectives of Metabolomics-Based Investigations in Coronary Heart Disease.Current atherosclerosis reports · 2025Review
- L-arginine supplement ameliorates dichlorvos-induced systemic inflammatory response and liver dysfunction in male wistar rats.Toxicology reports · 2025Article
- L-arginine overdose is a potential risk factor for myocardial injury in patients with type 2 diabetes.World journal of diabetes · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a well-known vasodilator produced by the vascular endothelium via the enzyme endothelial nitric oxide synthase (eNOS). The inadequate production of NO has been linked to elevated blood pressure (BP) in both human and animal studies, and might be due to substrate inaccessibility. This review aimed to investigate whether oral administration of the amino acids l-arginine (Arg) and l-citrulline (Cit), which are potential substrates for eNOS, could effectively reduce BP by increasing NO production. Both Arg and Cit are effective at increasing plasma Arg. Cit is approximately twice as potent, which is most likely due to a lower first-pass metabolism. The current data suggest that oral Arg supplementation can lower BP by 5.39/2.66 mmHg, which is an effect that is comparable with diet changes and exercise implementation. The antihypertensive properties of Cit are more questionable, but are likely in the range of 4.1/2.08 to 7.54/3.77 mmHg. The exact mechanism by which Cit and Arg exert their effect is not fully understood, as normal plasma Arg concentration greatly exceeds the Michaelis constant (K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.