Trial reportEuropean journal of cancer (Oxford, England : 1990)2019
Ten-year results of the Multicentric Italian Lung Detection trial demonstrate the safety and efficacy of biennial lung cancer screening.
Trial report in European journal of cancer (Oxford, England : 1990), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05766046 (Early Diagnosis of Lung Cancer of the Italian Pulmonary Screening Network), which is not on this map. Cited by 68 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Diagnosis of Lung Cancer of the Italian Pulmonary Screening Network (RISP): Comparative Analysis for the Use of Low Dose Computed Tomography and Promotion of Primary Prevention Interventions in Subjects at High Risk for Lung Cancer
Who cites it
68 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Screening for lung cancer: A systematic review of overdiagnosis and its implications.Molecular oncology · 2026Pooled it
- ESR Essentials: lung cancer screening with low-dose CT-practice recommendations by the European Society of Thoracic Imaging.European radiology · 2026Guideline
- Time to Benefit for Lung Cancer Screening: A Systematic Review and Survival Meta-Analysis.American journal of preventive medicine · 2025Pooled it
- [China National Lung Cancer Screening Guideline with Low-dose Computed Tomography (2023 Version)].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Guideline
- Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.The Cochrane database of systematic reviews · 2022Pooled it
- Lung Cancer Screening with Low-Dose CT: a Meta-Analysis.Journal of general internal medicine · 2020Pooled it
- Primary care outreach and decision counseling for lung cancer screening.Journal of medical screening · 2024Trial
- Over- and underscreening for lung cancer.Translational lung cancer research · 2026Review
- Rationale for the Nodule Management Protocol of the Australian National Lung Cancer Screening Program.Journal of medical imaging and radiation oncology · 2026Review
- Reimagining lung screening in women.The British journal of radiology · 2026Article
- Real-world description of patients with resected epidermal growth factor receptor mutation positive non-small cell lung carcinoma treated with adjuvant osimertinib in an early access program in Italy: the ELBA observational study.Frontiers in oncology · 2026Article
- Structured narrative review on lung cancer screening: current evidence, clinical practice implications and implementation insights from a multidisciplinary task force and patient representatives.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Lessons Learned From International Lung Cancer Screening Trials; People at Risk Deserve Screening for Early Detection.Respirology (Carlton, Vic.) · 2025Review
- Coronary calcium score and emphysema extent on different CT radiation dose protocols in lung cancer screening.European radiology · 2025Article
- Virtual lung screening trial (VLST): An in silico study inspired by the national lung screening trial for lung cancer detection.Medical image analysis · 2025Article
- Article
- Virtual Lung Screening Trial (VLST): AnArXiv · 2025Article
- Adherence to Annual Lung Cancer Screening and Rates of Cancer Diagnosis.JAMA network open · 2025Article
- Lung cancer screening by low-dose CT scan in France: final results of the DEP KP80 study after three rounds.EBioMedicine · 2024Article
- Deaths averted: An unbiased alternative to rate ratios for measuring the performance of cancer screening programs.Journal of medical screening · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundThe Multicentric Italian Lung Detection (MILD) trial demonstrated that prolonged low-dose computed tomography (LDCT) screening could achieve a 39% reduction in lung cancer (LC) mortality. We have here evaluated the long-term results of annual vs. biennial LDCT and the impact of screening intensity on overall and LC-specific mortality at 10 years. PATIENTS AND
methodsBetween 2005 and 2018, the MILD trial prospectively randomised the 2376 screening arm participants to annual (n = 1190) or biennial (n = 1186) LDCT, for a median screening period of 6.2 years and 23,083 person-years of follow-up. The primary outcomes were 10-year overall and LC-specific mortality, and the secondary end-points were the frequency of advanced-stage and interval LCs.
resultsThe biennial LDCT arm showed a similar overall mortality (hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.57-1.12) and LC-specific mortality at 10 years (HR 1.10, 95% CI 0.59-2.05), as compared with the annual LDCT arm. Biennial screening saved 44% of follow-up LDCTs in subjects with negative baseline LDCT, and 38% of LDCTs in all participants, with no increase in the occurrence of stage II-IV or interval LCs.
conclusionsThe MILD trial provides original evidence that prolonged screening beyond five years with biennial LDCT can achieve an LC mortality reduction comparable to annual LDCT, in subjects with a negative baseline examination.
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