Evidence map›Paper›PMID 31335806›Full record

ArticleAIDS (London, England)2019

Contributions of HIV, hepatitis C virus, and traditional vascular risk factors to peripheral artery disease in women.

Emily Cedarbaum, Yifei Ma, Rebecca Scherzer, Jennifer C Price, Adaora A Adimora, Marcas Bamman, Mardge Cohen, Margaret A Fischl, Kunihiro Matsushita, Igho Ofotokun and 7 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Cardiovascular Implications of Immune Disorders in Women.Circulation research · 2022 · on this map
    Review
  6. Review
  7. Article
  8. Review
  9. HIV and cardiovascular disease.The lancet. HIV · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 1 country.

Emily CedarbaumaDepartment of Medicine, University of California, San Francisco bMedical Service, Department of Veterans Affairs Medical Center, San Francisco, California cDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina dDepartment of Cell, Developmental, and Integrative Biology eDepartment of Medicine fDepartment of Neurology, University of Alabama, Birmingham, Alabama gDepartment of Medicine, Cook County Health and Hospitals System, Chicago, Illinois hDepartment of Medicine, University of Miami, Miami, Florida iDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland jDepartment of Medicine, Emory University, Atlanta, Georgia kDepartment of Medicine, Georgetown University Medical Center, Washington, District of Columbia lDepartment of Medicine, Columbia University, New York, New York mDepartment of Surgery, University of California, San Francisco, San Francisco, California nDepartment of Medicine, Albert Einstein College of Medicine, The Bronx, New York, USA.
Yifei Ma
Rebecca Scherzer
Jennifer C Price
Adaora A Adimora
Marcas Bamman
Mardge Cohen
Margaret A Fischl
Kunihiro Matsushita
Igho Ofotokun
Michael Plankey
Eric C Seaberg
Michael T Yin
Carl Grunfeld
Shant Vartanian
Anjali Sharma
Phyllis C Tien
University of California, San Francisco · USGeorgetown University · USJohns Hopkins University · USAlbert Einstein College of Medicine · USColumbia University · USCook County Health and Hospitals System · USEmory University · USSan Francisco VA Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146242NIAID NIH HHS K24 AI108516NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI087176NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NIA NIH HHS R21 AG059505NICHD NIH HHS U01 HD032632NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

objectivesHIV and hepatitis C virus (HCV) have been associated with cardiovascular disease (CVD), but it is unclear whether HIV and HCV are also associated with peripheral artery disease (PAD). We examined the association of HIV, HCV, and traditional CVD risk factors with PAD in the Women's Interagency HIV Study, a multicenter US cohort.

methodsIn this cross-sectional study, ankle-brachial index was estimated using Doppler ultrasound and manual sphygmomanometer in 1899 participants aged more than 40 years with HIV/HCV coinfection, HCV or HIV monoinfection, or neither infection. Multivariable logistic regression was used to estimate the odds of PAD (ankle-brachial index ≤0.9) after controlling for demographic, behavioral, and CVD risk factors.

resultsOver two-thirds were African-American, median age was 50 years, and PAD prevalence was 7.7% with little difference by infection status. After multivariable adjustment, neither HIV nor HCV infection was associated with greater odds of PAD. Factors associated with PAD included older age [adjusted odds ratio (aOR): 2.01 for age 61-70 vs. 40-50 years; 95% confidence interval (CI): 1.04, 3.87], Black race (aOR: 2.30; 95% CI: 1.15, 4.63), smoking (aOR: 1.27 per 10-pack-year increment; 95% CI: 1.09, 1.48), and higher SBP (aOR: 1.14 per 10 mmHg; 95% CI: 1.01, 1.28).

conclusionThe high PAD prevalence in this nationally representative cohort of women with or at risk for HIV is on par with general population studies in individuals a decade older than our study's median age. HIV and HCV infection are not associated with greater PAD risk relative to uninfected women with similar risk factors. Modifiable traditional CVD risk factors may be important early intervention targets in women with and at risk for HIV.

Indexed as

Ankle Brachial IndexCoinfectionCross-Sectional StudiesFemaleHepatitis CHIV InfectionsHumansLogistic ModelsMiddle AgedMultivariate AnalysisPeripheral Arterial DiseasePrevalenceProspective StudiesRisk FactorsSphygmomanometersUltrasonography, Doppler

Identifiers

PMID31335806
PMCPMC6774831
OpenAlexW2963051748

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.