Trial reportPain2019
Efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial.
Trial report in Pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 6 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Emerging trends and hotspots in cognitive behavioral therapy for chronic pain: a bibliometric analysis.Frontiers in medicine · 2026Pooled it
- Prevalence of Depression and Anxiety Among Adults With Chronic Pain: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Pooled it
- A systematic review of cognitive behavioral therapy-based interventions for comorbid chronic pain and clinically relevant psychological distress.Frontiers in psychology · 2023Pooled it
- Efficacy of different acupuncture therapies on postherpetic neuralgia: A Bayesian network meta-analysis.Frontiers in neuroscience · 2022Pooled it
- Co-Occurring Trauma and Non-Suicidal Self-Injury Among People With Chronic Pain: A Systematic Review.Current pain and headache reports · 2021Pooled it
- Effectiveness of a Transdiagnostic Emotion-Focused Treatment in Clinical Care: A Sequential Single-Case Experimental Design.European journal of pain (London, England) · 2026Trial
- Effect of internet-delivered exposure therapy versus healthy lifestyle promotion for patients with persistent physical symptoms (SOMEX1): a randomized controlled trial with planned moderator analysis.Psychological medicine · 2025Trial
- Online Dialectical Behavioral Therapy for Emotion Dysregulation in People With Chronic Pain: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Clinical Effectiveness and Cost-effectiveness of Videoconference-Based Integrated Cognitive Behavioral Therapy for Chronic Pain: Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice.Acta pharmacologica Sinica · 2026Article
- Temporal pathways between alexithymia, psychological distress, and pain: An autoregressive mediation analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Exposure-based Interventions for Chronic Pain and Bodily Symptoms: A Special Interest Meeting Report.Behaviour research and therapy · 2026Article
- Pain catastrophizing as a mediator of the relationship between pain intensity and depression: Evidence from chronic pain patients in Gaza.Global mental health (Cambridge, England) · 2026Article
- Chronic Pain and Newly Reported Frequent Feelings of Depression: A Nationally Representative Longitudinal Study in 2019-2020.Journal of pain research · 2026Article
- Article
- Approaching persistent pain and emotion dysregulation : Development of the hybrid emotion-focused exposure treatment.Schmerz (Berlin, Germany) · 2025Review
- PSD-95 Protein: A Promising Therapeutic Target in Chronic Pain.Molecular neurobiology · 2025Review
- The effectiveness of emotion-focused therapy on emotion regulation and coping strategies of women with somatic symptom.Journal of education and health promotion · 2025Article
- Physicians' Self-Reported Knowledge and Behaviors Related to Prescribing Opioids for Chronic Pain and Diagnosing Opioid Use Disorder, DocStyles, 2020.AJPM focus · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The comorbidity between chronic pain and emotional problems has proven difficult to address with current treatment options. This study addresses the efficacy of a transdiagnostic emotion-focused exposure treatment ("hybrid") for chronic pain patients with comorbid emotional problems. Adults (n = 115) with chronic musculoskeletal pain and functional and emotional problems were included in a 2-centre, parallel randomized controlled, open-label trial comparing this treatment to an active control condition receiving a guided Internet-delivered pain management treatment based on CBT principles (iCBT). The hybrid treatment (n = 58, 10-16 sessions) integrates exposure in vivo for chronic pain based on the fear-avoidance model with an emotion-regulation approach informed by procedures in Dialectical Behavior Therapy. The iCBT (n = 57; 8 treatment modules) addresses topics such as pain education, coping strategies, relaxation, problem solving, stress, and sleep management using standard CBT techniques. Patient-reported outcomes were assessed before and after treatment as well as at a 9-month primary end point. Across conditions, 78% participants completed post-treatment and 81% follow-up assessment. Intent-to-treat analyses showed that the hybrid had a significantly better post-treatment outcome on pain catastrophizing (d = 0.39) and pain interference (d = 0.63) and significantly better follow-up outcomes on depression (d = 0.43) and pain interference (d = 0.51). There were no differences on anxiety and pain intensity. Observed proportions of clinically significant improvement favoured the hybrid on all but one comparison, but no statistically significant differences were observed. We conclude that the hybrid emotion-focused treatment may be considered an acceptable, credible, and efficacious treatment option for chronic pain patients with comorbid emotional problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.