ArticleAnesthesiology2019
Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living.
Article in Anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06566469 (Effect of Dexmedetomidine-esketamine Combined Nasal Administration on Emergence Delirium in Elderly Patients After Surgery), which is not on this map. Cited by 68 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Dexmedetomidine-esketamine Combined Nasal Administration on Emergence Delirium in Elderly Patients After Surgery: a Randomized, Double-blind, Placebo-controlled Trial
Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Association of preoperative prognostic nutritional index with risk of postoperative delirium: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Association between frailty and postoperative delirium: a meta-analysis of cohort study.Aging clinical and experimental research · 2022Pooled it
- Pooled it
- Serum Albumin Level at Intensive Care Unit Admission and Delirium Duration and Severity in Critically Ill Adults.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2024Trial
- The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study.Journal of Alzheimer's disease : JAD · 2020Trial
- Construction and validation of a nomogram prediction model for the risk of delirium after hip arthroplasty in elderly patients.Medicine · 2026Article
- Long-Term Cognitive and Functional Outcomes of Anesthesia and Surgery in Patients with Dementia.Healthcare (Basel, Switzerland) · 2026Review
- Long-Term Cognitive and Functional Outcomes Following Postoperative Delirium and Liberal Fluid Fasting in Elderly Trauma Patients: A Prospective Single-Centre Study.Journal of clinical medicine · 2026Article
- Postoperative delirium: from bundles to precision prevention.Anesthesia and pain medicine · 2026Review
- Multi-output LSTM-based prediction of postoperative delirium: integrating baseline and perioperative data for enhanced risk stratification in older spine surgery patients.BioData mining · 2026Article
- Impaired peripheral perfusion during anesthesia is associated with postoperative delirium in older patients undergoing minimally invasive colorectal surgery: a retrospective observational study.Frontiers in medicine · 2026Article
- Extracellular vesicle signalling in perioperative neurocognitive disorders.Frontiers in immunology · 2026Review
- Delirium in the long-term care: a challenge for clinicians and researchers-the negative outcomes related to delirium: a scoping review.European geriatric medicine · 2025Article
- Development of a deep learning-based prediction model for postoperative delirium using intraoperative electroencephalogram in adults.NPJ digital medicine · 2025Article
- Article
- Reduced perioperative sensory impairment could lower postoperative delirium incidence: a before-and-after study in older patients with hip fracture.BMC geriatrics · 2025Article
- Preoperative quantitative quadriceps muscle ultrasound to predict POD for gastrointestinal surgery in older patients.BMC gastroenterology · 2025Article
- Long-term mortality impact of postoperative hyperactive delirium in older hip fracture surgery patients.BMC geriatrics · 2025Article
- Assessing delirium knowledge among health care professionals: findings from a scoping review.BMC nursing · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundPostoperative delirium is one of the most common complications in the elderly surgical population. However, its long-term outcomes remain largely to be determined. Therefore a prospective cohort study was conducted to determine the association between postoperative delirium and long-term decline in activities of daily living and postoperative mortality. The hypothesis in the present study was that postoperative delirium was associated with a greater decline in activities of daily living and higher mortality within 24 to 36 months after anesthesia and surgery.
methodsThe participants (at least 65 yr old) having the surgeries of (1) proximal femoral nail, (2) hip replacement, or (3) open reduction and internal fixation under general anesthesia were enrolled. The Confusion Assessment Method algorithm was administered to diagnose delirium before and on the first, second, and fourth days after the surgery. Activities of daily living were evaluated by using the Chinese version of the activities of daily living scale (range, 14 to 56 points), and preoperative cognitive function was assessed by using the Chinese Mini-Mental State Examination (range, 0 to 30 points). The follow-up assessments, including activities of daily living and mortality, were conducted between 24 and 36 months after anesthesia and surgery.
resultsOf 130 participants (80 ± 6 yr, 24% male), 34 (26%) developed postoperative delirium during the hospitalization. There were 32% of the participants who were lost to follow-up, resulting in 88 participants who were finally included in the data analysis. The participants with postoperative delirium had a greater decline in activities of daily living (16 ± 15 vs. 9 ± 15, P = 0.037) and higher 36-month mortality (8 of 28, 29% vs. 7 of 75, 9%; P = 0.009) as compared with the participants without postoperative delirium.
conclusionsPostoperative delirium was associated with long-term detrimental outcomes, including greater decline in activities of daily living and a higher rate of postoperative mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.