ArticleMolecular and cellular biology1988
Novel protein in human epidermal keratinocytes: regulation of expression during differentiation.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 82 citations in OpenAlex.
- Review
- Clinical implications of SPRR1A expression in diffuse large B-cell lymphomas: a prospective, observational study.BMC cancer · 2014Observational
- Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.Developmental cell · 2012Article
- Regulation of antimicrobial peptide expression in human gingival keratinocytes by interleukin-1α.Archives of oral biology · 2011Article
- Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease.Investigative ophthalmology & visual science · 2008Article
- Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.Molecular medicine (Cambridge, Mass.) · 1999Article
- Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation.Molecular and cellular biology · 1996Article
- Regulation of transmembrane signalling system during senescence of human epidermal keratinocytes.Archives of dermatological research · 1996Article
- Identification of two cDNA clones encoding small proline-rich proteins expressed in sheep ruminal epithelium.The Biochemical journal · 1996Article
- Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.The Journal of cell biology · 1994Article
- Overexpression of human loricrin in transgenic mice produces a normal phenotype.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Loricrin immunoreactivity in human skin: localization to specific granules (L-granules) in acrosyringia.Archives of dermatological research · 1993Article
- Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes.Nucleic acids research · 1990Article
- Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.Molecular and cellular biology · 1988Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, two groups of cDNA clones have been isolated from human epidermal keratinocytes; the clones correspond to genes whose expression is stimulated by exposure of the cells to UV light or treatment with 4-nitroquinoline 1-oxide or 12-O-tetradecanoylphorbol 13-acetate (T. Kartasova and P. van de Putte, Mol. Cell. Biol. 8:2195-2203, 1988). The proteins predicted by the nucleotide sequence of both groups of cDNAs are small (8 to 10 kilodaltons), are exceptionally rich in proline, glutamine, and cysteine, and contain repeating elements with a common sequence, PK PEPC. These proteins were designated sprI and sprII (small, proline rich). Here we describe the characterization of the sprIa protein, which is encoded by one of the group 1 cDNAs. The expression of this protein during keratinocyte differentiation in vitro and the distribution of the sprIa protein in some human tissues was studied by using a specific rabbit antiserum directed against a synthetic polypeptide corresponding to the 30 amino acids of the C-terminal region of the sprIa gene product. The results indicate that the expression of the sprIa protein is stimulated during keratinocyte differentiation both in vitro and in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.