ArticleMolecular and cellular biology1988
Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 166 citations in OpenAlex.
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- Weighted Gene Co-Expression Network Analysis of Oxymatrine in Psoriasis Treatment.Journal of inflammation research · 2023Article
- Biomechanical Forces Regulate Gene Transcription During Stretch-Mediated Growth of Mammalian Neurons.Frontiers in neuroscience · 2020Article
- The Molecular Revolution in Cutaneous Biology: EDC and Locus Control.The Journal of investigative dermatology · 2017Review
- Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Clinical implications of SPRR1A expression in diffuse large B-cell lymphomas: a prospective, observational study.BMC cancer · 2014Observational
- Ovarian reserve status in young women is associated with altered gene expression in membrana granulosa cells.Molecular human reproduction · 2012Article
- Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2012Article
- The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1a.Experimental neurology · 2012Article
- Transcriptomic analysis of the temporal host response to skin infestation with the ectoparasitic mite Psoroptes ovis.BMC genomics · 2010Article
- Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis.American journal of respiratory cell and molecular biology · 2009Article
- Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury.The Journal of comparative neurology · 2009Article
- Ancient origin of the gene encoding involucrin, a precursor of the cross-linked envelope of epidermis and related epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease.Investigative ophthalmology & visual science · 2008Article
- Selective temporal and regional alterations of Nogo-A and small proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor (NgR) occur following traumatic brain injury in the rat.Experimental neurology · 2006Article
- Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein.The EMBO journal · 2004Article
- Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Targeted ablation of the murine involucrin gene.The Journal of cell biology · 2000Article
- Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By screening of a cDNA library made on mRNA isolated from UV-irradiated human epidermal keratinocytes for sequences whose relative concentration increases in the cytoplasm after irradiation, we have isolated 40 cDNA clones (T. Kartasova, B. J. C. Cornelissen, P. Belt, and P. van de Putte, Nucleic Acids Res. 15:5945-5962, 1987). Here we describe two distinct groups of cDNA clones which do not cross-hybridize to each other but nevertheless encode proteins of very similar primary structure. These polypeptides are small (8 to 10 kilodaltons) and exceptionally rich in proline, cysteine, and glutamine and have similar repeating elements not found elsewhere. The new proteins were designated sprI and sprII (small, proline rich). The presence of prolines and cysteines suggests that they may be either structural proteins with a strong secondary structure or metal-binding proteins such as metallothioneins. Southern blot and sequence analyses of the cDNAs indicate that at least the sprII group of clones represents a family of related genes. The nucleotide sequence of both groups seems to be conserved upon evolution. The level of mRNAs corresponding to the two groups of cDNAs is increased in the cytoplasm of human epidermal keratinocytes after both UV irradiation and treatment with 4-nitroquinoline 1-oxide or 12-O-tetradecanoylphorbol 13-acetate.
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