ArticleMolecular and cellular biology1988
Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Changes in replication, nuclear location, and expression of the Igh locus after fusion of a pre-B cell line with a T cell line.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator.Molecular and cellular biology · 1999Article
- Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element.The EMBO journal · 1995Article
- Negative regulation of transcription in eukaryotes.The Biochemical journal · 1993Review
- The octamer/mu E4 region of the immunoglobulin heavy-chain enhancer mediates gene repression in myeloma x T-lymphoma hybrids.Molecular and cellular biology · 1993Article
- Differential susceptibility of mouse Lyt-2 and Lyt-3 genes to negative regulation.Immunogenetics · 1993Article
- Extinction of the HPV18 upstream regulatory region in cervical carcinoma cells after fusion with non-tumorigenic human keratinocytes under non-selective conditions.The EMBO journal · 1991Article
- Positive and negative regulation of immunoglobulin gene expression by a novel B-cell-specific enhancer element.Molecular and cellular biology · 1991Article
- Extinction of retinol-binding protein gene expression in somatic cell-hybrids: identification of the target sequences.Nucleic acids research · 1990Article
- Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice.Molecular and cellular biology · 1990Article
- Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells.The EMBO journal · 1990Article
- The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes.Molecular and cellular biology · 1990Article
- Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor.The EMBO journal · 1990Article
- Nucleotide-sequence-specific de novo methylation in a somatic murine cell line.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- The rat albumin gene promoter is appropriately regulated in transient but not in stable transfections.Nucleic acids research · 1988Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The tissue-specific expression of immunoglobulin genes can be partially explained by a requirement for activating factors found only in B lymphocytes and their derivatives. However, loss of immunoglobulin expression upon fusion of an immunoglobulin-producing myeloma cell with a T lymphoma cell (BW5147) or fibroblast (L cell) suggests that negatively acting factors also play a role in the tissue specificity of immunoglobulin genes. Expression of a cloned immunoglobulin heavy-chain gene introduced into myeloma cells was suppressed after fusion of the myeloma transformants with BW5147. The presence of either the immunoglobulin heavy-chain enhancer or promoter conferred suppression, under similar conditions, upon a heterologous gene that is normally expressed in both B and T lymphocytes. These immunoglobulin heavy-chain gene control regions, or gene modifications induced by them, are subject to negative control by T-lymphocyte-derived factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.