SynthesisRetina (Philadelphia, Pa.)2020
FIRST FAILED MACULAR HOLE SURGERY OR REOPENING OF A PREVIOUSLY CLOSED HOLE: Do We Gain by Reoperating?-A Systematic Review and Meta-analysis.
Synthesis in Retina (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Amniotic membrane transplantation for macular holes: decoding the optimal approach-inlay or overlay?International ophthalmology · 2025Pooled it
- Short-term visual acuity responder rates after full-thickness macular hole surgery stratified by hole size: a retrospective cohort study.BMC ophthalmology · 2026Article
- Temporal Arcuate Relaxing Retinotomy for Persistent Full-Thickness Macular Holes: Anatomical and Functional Assessment.Journal of clinical medicine · 2026Article
- Visual and anatomical outcomes of full-thickness macular hole surgery and associated factors in selected hospitals in Tanzania.PloS one · 2026Article
- Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes.International journal of retina and vitreous · 2024Article
- Closure rates and patterns after light silicone oil tamponade for persistent full-thickness macular holes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Relaxing Retinotomy in Recurrent and Refractory Full-Thickness Macular Holes: The State of the Art.Life (Basel, Switzerland) · 2023Review
- Femtosecond laser-cut autologous anterior lens capsule transplantation to treat refractory macular holes.Eye (London, England) · 2023Article
- Surgical classification for large macular hole: based on different surgical techniques results: the CLOSE study group.International journal of retina and vitreous · 2023Article
- Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy.BMC ophthalmology · 2022Article
- Role of intraretinal cysts in the prediction of postoperative closure and photoreceptor damages of the idiopathic full-thickness macular hole.BMC ophthalmology · 2022Article
- Macular Holes: Main Clinical Presentations, Diagnosis, and Therapies.Journal of ophthalmology · 2022Review
- Internal Limiting Membrane Peeling and Gas Tamponade For Full-Thickness Macular Holes of Different Etiology - Is It Still Relevant?Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Persistent macular holes - what is the best strategy for revision?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Revision Surgery for Idiopathic Macular Hole after Failed Primary Vitrectomy.Journal of ophthalmology · 2021Article
- Secondary Vitrectomy with Internal Limiting Membrane Plug due to Persistent Full-Thickness Macular Hole OCT-Angiography and Microperimetry Features: Case Series.Journal of ophthalmology · 2020Article
- The Hole Story: Spontaneous Closure after Reopening.Case reports in ophthalmologyArticle
- Spontaneous closure of a macular hole in an unusually long time after primary vitrectomy.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
- Commented on byCorrespondence.2020
- Commented on byReply.2020
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate repeated surgery for idiopathic full-thickness macular hole that failed to close (FTC) after first surgery or reopened (RO) once originally closed.
methodsSystematic review and meta-analysis. Pubmed.gov and Cochrane Library were searched for studies in English presenting outcomes of idiopathic full-thickness macular hole that FTC or RO (case reports/series of <5 cases excluded). OUTCOME MEASURES: Anatomical closure, postoperative best-corrected visual acuity, intraoperative/postoperative complications, and patient-reported outcomes. Meta-analysis was performed on aggregate and available individual participant data sets using the metafor package in R.
resultsTwenty-eight eligible studies were identified. After reoperation, pooled estimates for anatomical closure were 78% (95% confidence interval 71-84%) and 80% (95% confidence interval 66-89%) for FTC and RO groups, respectively. On average, best-corrected visual acuity improved in both groups. However, only 15% (28 of 189 eyes) of FTC eyes achieved best-corrected visual acuity of ≥6/12. The pooled estimated probability of ≥2-line best-corrected visual acuity improvement was 58% in the FTC group (95% confidence interval 45-71%); meta-analysis was not possible in the RO group. The most common complication was cataract.
conclusionReoperation for FTC or RO idiopathic full-thickness macular hole achieved a clinically meaningful visual acuity improvement in more than half of patients; high levels of vision (≥6/12), however, were uncommon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.