Evidence map›Paper›PMID 31335281›Full record

ArticleRadiology2019

Single-Dose Neoadjuvant AKT Pathway Inhibitor Reduces Growth of Hepatocellular Carcinoma after Laser Thermal Ablation in Small-Animal Model.

Danielle E Jondal, Scott M Thompson, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Lewis R Roberts, Matthew R Callstrom, David A Woodrum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Venous endothelial remodeling mediated byFrontiers in immunology · 2026
    Article
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Danielle E JondalFrom the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-9447-9646
Scott M ThompsonFrom the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-7853-3278
Kim A ButtersFrom the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.
Bruce E KnudsenFrom the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.
Jill L AndersonFrom the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.
Lewis R RobertsFrom the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.
Matthew R CallstromFrom the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.ORCID 0000-0001-5505-1882
David A WoodrumFrom the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.
Mayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesTL1RR024152 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$2.5M
Mayo Clinic Center for Translational Science ActivitiesTL1TR000137 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$2.1M
Regulation of molecular thermal ablative resistance in hepatocellular carcinomaR01CA177686 · NCI · MAYO CLINIC ROCHESTER · PI WOODRUM, DAVID A · 2013 to 2017
$1.6M
NCATS NIH HHS TL1 TR000137NCI NIH HHS R01 CA177686NCRR NIH HHS TL1 RR024152
6 · The paper itself

Abstract

BackgroundLocal recurrence following thermal ablation of hepatocellular carcinoma (HCC) larger than 2-3 cm remains a challenging clinical problem. Prior studies suggest that phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)-dependent protein kinase B (AKT) signaling mediates HCC cell survival caused by moderate heat stress in vitro

Indexed as

Ablation TechniquesAnimalsAntineoplastic AgentsCarcinoma, HepatocellularCombined Modality TherapyDisease Models, AnimalImidazolesLiver NeoplasmsMiceMice, NudeNeoadjuvant TherapyPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuinolinesSignal TransductionTOR Serine-Threonine KinasesAntineoplastic AgentsdactolisibImidazolesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuinolinesTOR Serine-Threonine Kinases

Identifiers

PMID31335281
PMCPMC6736176
OpenAlexW2963058067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.