Evidence map›Paper›PMID 31335145›Full record

ArticleJournal of proteome research2019

Proteomic Analysis of

Melanie J Shears, Raja Sekhar Nirujogi, Kristian E Swearingen, Santosh Renuse, Satish Mishra, Panga Jaipal Reddy, Robert L Moritz, Akhilesh Pandey, Photini Sinnis

Abstract read
In one paragraph

Article in Journal of proteome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Flp/Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Autophagy Pathways in the Genesis ofLife (Basel, Switzerland) · 2022
    Article
  14. Host-parasite interactions duringFrontiers in immunology · 2022
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites.Frontiers in cellular and infection microbiology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melanie J ShearsDepartment of Molecular Microbiology & Immunology , Johns Hopkins Bloomberg School of Public Health , 615 North Wolfe Street , Baltimore , Maryland 21205 , United States.ORCID 0000-0002-8226-4354
Raja Sekhar NirujogiDepartment of Biological Chemistry , Johns Hopkins School of Medicine , 733 N. Broadway , Baltimore , Maryland 21205 , United States.
Kristian E SwearingenInstitute for Systems Biology , 401 Terry Avenue , North Seattle , Washington 98109 , United States.
Santosh RenuseDepartment of Biological Chemistry , Johns Hopkins School of Medicine , 733 N. Broadway , Baltimore , Maryland 21205 , United States.
Satish MishraDepartment of Molecular Microbiology & Immunology , Johns Hopkins Bloomberg School of Public Health , 615 North Wolfe Street , Baltimore , Maryland 21205 , United States.
Panga Jaipal ReddyInstitute for Systems Biology , 401 Terry Avenue , North Seattle , Washington 98109 , United States.
Robert L MoritzInstitute for Systems Biology , 401 Terry Avenue , North Seattle , Washington 98109 , United States.ORCID 0000-0002-3216-9447
Akhilesh PandeyDepartment of Biological Chemistry , Johns Hopkins School of Medicine , 733 N. Broadway , Baltimore , Maryland 21205 , United States.ORCID 0000-0001-9943-6127
Photini SinnisDepartment of Molecular Microbiology & Immunology , Johns Hopkins Bloomberg School of Public Health , 615 North Wolfe Street , Baltimore , Maryland 21205 , United States.ORCID 0000-0003-2954-7547

Funding

Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computingR01GM087221 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC, MORITZ, ROBERT L · 2010 to 2021
$6.0M
Structure and Function of the Circumsporozoite ProteinR01AI056840 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SINNIS, PHOTINI · 2005 to 2014
$3.8M
The Skin Phase of Malaria Infection (Sharon Patray Diversity Supplement)R01AI132359 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SINNIS, PHOTINI · 2017 to 2021
$2.7M
Elucidating phosphorylation signaling networks in infectious Plasmodium parasitesK25AI119229 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI SWEARINGEN, KRISTIAN EDWARD · 2015 to 2019
$682k
FAIMS-Selected Reaction Monitoring to Quantitative Protein Networks in DiseaseS10RR027584 · NCRR · INSTITUTE FOR SYSTEMS BIOLOGY · PI MORITZ, ROBERT L · 2011 to 2011
$576k
Request for Zeiss LSM 510 MP Multiphoton Imaging SystemS10RR024550 · NCRR · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2008 to 2008
$500k
NCRR NIH HHS S10 RR024550NCRR NIH HHS S10 RR027584NIAID NIH HHS K25 AI119229NIAID NIH HHS R01 AI056840NIAID NIH HHS R01 AI132359NIGMS NIH HHS R01 GM087221
6 · The paper itself

Abstract

The pre-erythrocytic liver stage of the malaria parasite, comprising sporozoites and the liver stages into which they develop, remains one of the least understood parts of the lifecycle, in part owing to the low numbers of parasites. Nonetheless, it is recognized as an important target for antimalarial drugs and vaccines. Here we provide the first proteomic analysis of merosomes, which define the final phase of the liver stage and are responsible for initiating the blood stage of infection. We identify a total of 1879 parasite proteins, and a core set of 1188 proteins quantitatively detected in every biological replicate, providing an extensive picture of the protein repertoire of this stage. This unique data set will allow us to explore key questions about the biology of merosomes and hepatic merozoites.

Indexed as

ProteomicsAnimalsAnophelesErythrocytesHepatocytesHumansLife Cycle StagesLiverMalariaMerozoitesMicePlasmodium bergheiexoerythrocytic stageliver stagesmalariamerosomesPEXELproteomicssporozoites

Identifiers

PMID31335145
PMCPMC7105274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.