ArticleJournal of veterinary internal medicine2019
Prevalence of Babesia spp. and clinical characteristics of Babesia vulpes infections in North American dogs.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- A cost-effective and rapid TE-based DNA extraction for near point-of-care detection of Babesia spp. by RPA/CRISPR-Cas12a.Molecular biology reports · 2026Article
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- Molecular analysis of vector-borne pathogens in red foxes (International journal for parasitology. Parasites and wildlife · 2025Article
- Case report: First autochthonousFrontiers in veterinary science · 2025Article
- Survey forInternational journal for parasitology. Parasites and wildlife · 2024Article
- Diversity of Babesia spp. in skunks from selected states in the United States of America.Parasite (Paris, France) · 2024Article
- The Diverse Pathogenicity of VariousPathogens (Basel, Switzerland) · 2023Review
- First Molecular Evidence ofPathogens (Basel, Switzerland) · 2023Article
- Canine Babesiosis Caused by LargeAnimals : an open access journal from MDPI · 2023Review
- A Forty-Year Analysis of the Literature onInternational journal of environmental research and public health · 2023Review
- Use of In-Clinic Diagnostic Kits for the Detection of Seropositivity toPathogens (Basel, Switzerland) · 2023Article
- Pathogenesis of Anemia in Canine Babesiosis: Possible Contribution of Pro-Inflammatory Cytokines and Chemokines-A Review.Pathogens (Basel, Switzerland) · 2023Review
- Cross-sectional analysis ofFrontiers in veterinary science · 2023Article
- A retrospective study of vector borne disease prevalence among anemic dogs in North Carolina.PloS one · 2023Article
- Prevalence and geographic distribution ofInternational journal for parasitology. Parasites and wildlife · 2022Article
- Vector-borne disease and its relationship to hematologic abnormalities and microalbuminuria in retired racing and show-bred greyhounds.Journal of veterinary internal medicine · 2022Article
- Article
- Babesiosis and Theileriosis in North America.Pathogens (Basel, Switzerland) · 2022Review
- Canine and Feline Parasitology: Analogies, Differences, and Relevance for Human Health.Clinical microbiology reviews · 2021Review
- Simultaneous Exposure toPathogens (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBabesiosis is an important cause of thrombocytopenia and hemolytic anemia in dogs. Babesia vulpes, reported in European dogs and North American foxes, rarely has been reported in domestic North American dogs. Newly optimized polymerase chain reaction (PCR) primers facilitate more sensitive amplification of B. vulpes DNA.
objectivesTo determine the prevalence of Babesia sp. infections in dogs being tested for Babesia infection, and to describe co-infections and clinicopathologic abnormalities in B. vulpes positive dogs. ANIMALS: Dog blood or tissue samples (n = 9367) submitted to a diagnostic laboratory between June 2015 and June 2018 were tested using an optimized Babesia PCR assay.
methodsComprehensive canine vector-borne disease diagnostic testing was performed on convenience samples.
resultsBabesia sp. DNA was amplified from 269/9367 (2.9%) North American dogs. Babesia sp. infections included B. gibsoni monoinfection (157; 1.7%), B. vulpes monoinfection (19; 0.20%), and B. gibsoni and B. vulpes coinfection (29; 0.31%). Forty-three of the 48 total B. vulpes-infected dogs were American Pit Bull Terrier-type breeds, of which 36 historically were involved with dog fights. Coinfections with Mycoplasma, Dirofilaria immitis, or Wolbachia and coexposures to Bartonella, Ehrlichia, and Rickettsia spp. were documented in B. vulpes-infected dogs. Clinicopathologic data in B. vulpes-infected dogs both with and without coinfections included anemia, thrombocytopenia, hyperglobulinemia, hypoalbuminemia, and proteinuria. CONCLUSIONS AND CLINICAL IMPORTANCE: Babesia vulpes infection in domestic North American dogs is commonly found in conjunction with other coinfections, including B. gibsoni and hemotropic Mycoplasma. Similar to B. gibsoni, dog-to-dog transmission of B. vulpes may be a frequent mode of transmission.
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