ArticleJournal of biophotonics2019
Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium.
Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Vis-OCT Explorer: an open-source software for visible-light optical coherence tomography data processing.Biomedical optics express · 2026Article
- Article
- Hyperspectral retinal imaging biomarkers of ocular and systemic diseases.Eye (London, England) · 2025Review
- Advancing hyperspectral imaging and machine learning tools toward clinical adoption in tissue diagnostics: A comprehensive review.APL bioengineering · 2024Review
- Needle guidance with Doppler-tracked polarization-sensitive optical coherence tomography.Journal of biomedical optics · 2023Article
- A comparison of optophysiological biomarkers of photoreceptor stress and phototoxicity in BALB/cJ, B6 (Cg)-Tyrc-2J/J, and C57Bl/6J mouse strains.Frontiers in ophthalmology · 2023Article
- Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1-/- Mice Using Intensity, Polarization, and Spectroscopic OCT.Translational vision science & technology · 2022Article
- A Review of Watershed Implementations for Segmentation of Volumetric Images.Journal of imaging · 2022Review
- Relationship between axial resolution and signal-to-noise ratio in optical coherence tomography.Optics letters · 2022Article
- Reconstruction of visible light optical coherence tomography images retrieved from discontinuous spectral data using a conditional generative adversarial network.Biomedical optics express · 2021Article
- Rapid pseudo-H&E imaging using a fluorescence-inbuilt optical coherence microscopic imaging system.Biomedical optics express · 2021Article
- Melanins as Sustainable Resources for Advanced Biotechnological Applications.Global challenges (Hoboken, NJ) · 2021Review
- Melanin concentration and depolarization metrics measurement by polarization-sensitive optical coherence tomography.Scientific reports · 2020Article
- Visible-Light Optical Coherence Tomography Fibergraphy for Quantitative Imaging of Retinal Ganglion Cell Axon Bundles.Translational vision science & technology · 2020Article
- Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium.Journal of biophotonics · 2019Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Previous studies for melanin visualization in the retinal pigment epithelium (RPE) have exploited either its absorption properties (using photoacoustic tomography or photothermal optical coherence tomography [OCT]) or its depolarization properties (using polarization sensitive OCT). However, these methods are only suitable when the melanin concentration is sufficiently high. In this work, we present the concept of hyperspectral OCT for melanin visualization in the RPE when the concentration is low. Based on white light OCT, a hyperspectral stack of 27 wavelengths (440-700 nm) was created in post-processing for each depth-resolved image. Owing to the size and shape of the melanin granules in the RPE, the variations in backscattering coefficient as a function of wavelength could be identified-a result which is to be expected from Mie theory. This effect was successfully identified both in eumelanin-containing phantoms and in vivo in the low-concentration Brown Norway rat RPE.
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Registered trials
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