ArticleHippocampus2019
The role of hippocampal subfield volume and fornix microstructure in episodic memory across the lifespan.
Article in Hippocampus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Age-related differences in hippocampal subfield volumes across the human lifespan: A meta-analysis.Hippocampus · 2023Pooled it
- Cumulative exposure to cannabis and hippocampus MRI in middle age: results from the coronary artery risk development in young adults (CARDIA) study.Translational psychiatry · 2026Article
- Longitudinal analysis of hippocampal subfield atrophy and network centrality associated with cognitive decline in Alzheimer's disease progression.Medical physics · 2026Article
- Article
- Altered cerebellar volumes and intrinsic cerebellar networks in patients with transient global amnesia.Brain imaging and behavior · 2024Article
- Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI).Neurobiology of aging · 2023Article
- Investigation of genetic variants and causal biomarkers associated with brain aging.Scientific reports · 2023Article
- A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics.Frontiers in neuroinformatics · 2023Article
- Hippocampal microstructure, but not macrostructure, mediates age differences in episodic memory.Frontiers in aging neuroscience · 2023Article
- The fornix supports episodic memory during childhood.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Structure-Function Dissociations of Human Hippocampal Subfield Stiffness and Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts.Human brain mapping · 2022Review
- Hippocampal acidity and volume are differentially associated with spatial navigation in older adults.NeuroImage · 2021Article
- Age affects white matter microstructure and episodic memory across the older adult lifespan.Neurobiology of aging · 2021Article
- Diffusion properties of the fornix assessed by deterministic tractography shows age, sex, volume, cognitive, hemispheric, and twin relationships in young adults from the Human Connectome Project.Brain structure & function · 2021Article
- Hippocampal and Parahippocampal Gray Matter Structural Integrity Assessed by Multimodal Imaging Is Associated with Episodic Memory in Old Age.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Contribution of iron and Aβ to age differences in entorhinal and hippocampal subfield volume.Neurology · 2020Article
- Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan.Brain : a journal of neurology · 2020Article
- Dissecting the Fornix in Basic Memory Processes and Neuropsychiatric Disease: A Review.Brain connectivity · 2020Review
- Hippocampal Subfields and Limbic White Matter Jointly Predict Learning Rate in Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Advancing age is associated with both declines in episodic memory and degradation of medial temporal lobe (MTL) structure. The contribution of MTL to episodic memory is complex and depends upon the interplay among hippocampal subfields and surrounding structures that participate in anatomical connectivity to the cortex through inputs (parahippocampal and entorhinal cortices) and outputs (fornix). However, the differential contributions of MTL system components in mediating age effects on memory remain unclear. In a sample of 177 healthy individuals aged 20-94 we collected high-resolution T1-weighted, ultrahigh-resolution T2/PD, and diffusion tensor imaging (DTI) MRI sequences on a 3T Phillips Achieva scanner. Hippocampal subfield and entorhinal cortex (ERC) volumes were measured from T2/PD scans using a combination of manual tracings and training of a semiautomated pipeline. Parahippocampal gyrus volume was estimated using Freesurfer and DTI scans were used to obtain diffusion metrics from tractography of the fornix. Item and associative episodic memory constructs were formed from multiple tests. Competing structural equation models estimating differential association among these structural variables were specified and tested to investigate whether and how fornix diffusion and volume of parahippocampal gyrus, ERC, and hippocampal subfields mediate age effects on associative and/or item memory. The most parsimonious, best-fitting model included an anatomically based path through the MTL as well as a single hippocampal construct which combined all subfields. Results indicated that fornix microstructure independently mediated the effect of age on associative memory, but not item memory. Additionally, all regions and estimated paths (including fornix) combined to significantly mediate the age-associative memory relationship. These findings suggest that preservation of fornix connectivity and MTL structure with aging is important for maintenance of associative memory performance across the lifespan.
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