ArticleCurrent developments in nutrition2019
Determination of Vitamin D and Its Metabolites in Human Brain Using an Ultra-Pressure LC-Tandem Mass Spectra Method.
Article in Current developments in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Associations among Dietary Intakes, Blood Biomarkers, and Postmortem Brain Tissue Concentrations of Vitamins D and K in Older Adults.The Journal of nutrition · 2026Article
- The Role of Vitamin D and Vitamin D Receptor in Sepsis.Current issues in molecular biology · 2025Review
- Determination of 25-Hydroxyvitamin DBiomedical chromatography : BMC · 2025Article
- Vitamin D beyond the blood: Tissue distribution of vitamin D metabolites after supplementation.Life sciences · 2024Review
- A Sensitive Method for Determination 1,25-Dihydroxyvitamin D3 in Human Brain using Ultra-Pressure Liquid Chromatography Tandem Mass Spectrometry.Current developments in nutrition · 2024Article
- Role of Calcitriol and Vitamin D Receptor (International journal of molecular sciences · 2024Review
- A highly sensitive LC-MS/MS method for quantitative determination of 7 vitamin D metabolites in mouse brain tissue.Analytical and bioanalytical chemistry · 2023Article
- Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders.Nutrients · 2022Review
- Vitamin D and Parkinson's Disease.Nutrients · 2022Review
- Role of Vitamin D in Cognitive Dysfunction: New Molecular Concepts and Discrepancies between Animal and Human Findings.Nutrients · 2021Review
- Review
- Implications of Vitamin D Research in Chickens can Advance Human Nutrition and Perspectives for the Future.Current developments in nutrition · 2021Article
- Vitamin D and Vitamin K Concentrations in Human Brain Tissue Are Influenced by Freezer Storage Time: The Memory and Aging Project.The Journal of nutrition · 2021Article
- Vitamin D: Brain and Behavior.JBMR plus · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLow serum total 25-hydroxyvitamin D
objectivesThe aim of this study was to develop and validate a method to quantify vitamin D
methodsThe assay developments were performed using porcine brains. Liquid extraction was used in homogenized samples (∼0.1 g each) prior to analysis by LC-MS/MS with electrospray ionization following derivatization with 4-phenyl-1,2,4-triazoline-3,5-dione. This method was then applied to the determination of vitamin D and its metabolites in a whole human brain obtained from the National Development and Research Institutes.
resultsThe method showed good linearity of vitamin D
conclusionsTo the best of our knowledge, this study is the first report of the measurement of concentrations of vitamin D metabolites in human brain. This validated method can be applied to postmortem studies to obtain accurate information about the presence and role of vitamin D and its metabolites in human brain and neurodegenerative diseases.
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