ArticleHepatology communications2019
Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes.
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Article in Hepatology communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Genetics of MASLD: a diabetes perspective.Diabetologia · 2026Review
- Genetic and genomic insights across the steatotic liver disease spectrum.Clinical and molecular hepatology · 2026Review
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- Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment.The Journal of clinical investigation · 2025Review
- PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease.Liver international : official journal of the International Association for the Study of the Liver · 2025Review
- Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease.Clinical and molecular hepatology · 2025Review
- A Very Low-Carbohydrate Program in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease and Phospholipase Domain-Containing Protein 3 Risk Genotype: Pre-Post Intervention Study.JMIR formative research · 2025Article
- Therapeutic Potential ofFood science & nutrition · 2025Article
- Genetic risk accentuates dietary effects on hepatic steatosis, inflammation and fibrosis in a population-based cohort.Journal of hepatology · 2024Article
- Hepatic glucose metabolism in the steatotic liver.Nature reviews. Gastroenterology & hepatology · 2024Review
- Effect of donorEClinicalMedicine · 2024Article
- Unraveling the pathogenesis of non-alcoholic fatty liver diseases through genome-wide association studies.Journal of gastroenterology and hepatology · 2023Review
- Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants.International journal of molecular sciences · 2023Article
- PNPLA3 Genotype and Diabetes Identify Patients With Nonalcoholic Fatty Liver Disease at High Risk of Incident Cirrhosis.Gastroenterology · 2023Article
- Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease.Metabolites · 2023Article
- Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD.Frontiers in endocrinology · 2023Review
- Contribution of a genetic risk score to ethnic differences in fatty liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2022Article
- Influence of Type 2 Diabetes in the Association ofBiomedicines · 2022Article
- The genetic interactions between non-alcoholic fatty liver disease and cardiovascular diseases.Frontiers in genetics · 2022Review
Corrections and comments
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Authors and funding
30 authors at 9 institutions in 2 countries.
Llilda BarataDivision of Statistical Genomics, Department of Genetics Washington University School of Medicine St. Louis MO.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics Washington University School of Medicine St. Louis MO.
Lawrence F BielakDepartment of Epidemiology, School of Public Health University of Michigan Ann Arbor MI.
Brian HalliganDivision of Gastroenterology, Department of Internal Medicine, Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI.
Abigail S BaldridgeDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, LABioMed and the Department of Pediatrics Harbor-University of California Los Angeles Medical Center Torrance CA.
Laura M Yerges-ArmstrongDepartment of Medicine University of Maryland School of Medicine Baltimore MD.
Albert V SmithDepartment of Biostatistics, School of Public Health University of Michigan Ann Arbor MI.
Jie YaoInstitute for Translational Genomics and Population Sciences, LABioMed and the Department of Pediatrics Harbor-University of California Los Angeles Medical Center Torrance CA.
Nicholette D PalmerDepartment of Biochemistry Wake Forest School of Medicine Winston-Salem NC.
Lisa B VanWagnerDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID https://orcid.org/0000-0002-6264-2573
J Jeffrey CarrDepartment of Radiology Vanderbilt University School of Medicine Nashville TN.
Yii-Der I ChenInstitute for Translational Genomics and Population Sciences, LABioMed and the Department of Pediatrics Harbor-University of California Los Angeles Medical Center Torrance CA.
Matthew AllisonDepartment of Family Medicine and Public Health University of California San Diego San Diego CA.
Matthew J BudoffDivision of Cardiology Los Angeles Biomedical Research Institute Torrance CA.
Samuel K HandelmanDivision of Gastroenterology, Department of Internal Medicine, Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health University of Michigan Ann Arbor MI.
Thomas H MosleyDepartment of Medicine, Division of Geriatrics University of Mississippi Medical Center Jackson MS.
Kathleen RyanDepartment of Medicine University of Maryland School of Medicine Baltimore MD.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences National Institute of Aging Bethesda MD.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences National Institute of Aging Bethesda MD.
Vilmundur GudnasonIcelandic Heart Association Kopavogur Iceland.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, LABioMed and the Department of Pediatrics Harbor-University of California Los Angeles Medical Center Torrance CA.
Myriam FornageUniversity of Texas Health Science Center Houston TX.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.
Ingrid B BoreckiDivision of Statistical Genomics, Department of Genetics Washington University School of Medicine St. Louis MO.
Jeffrey R O'ConnellDepartment of Medicine University of Maryland School of Medicine Baltimore MD.
Patricia A PeyserDepartment of Epidemiology, School of Public Health University of Michigan Ann Arbor MI.
Elizabeth K SpeliotesDivision of Gastroenterology, Department of Internal Medicine, Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics Washington University School of Medicine St. Louis MO.
University of Michigan · USUniversity of California, Los Angeles · USUniversity of Maryland, Baltimore · USNorthwestern University · USNational Institute on Aging · USThe Lundquist Institute · USUniversity of California San Diego · USVanderbilt University · USWake Forest University · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MGenetic Architecture of Adiposity in Multiple Large CohortsR01DK089256 · NIDDK · WASHINGTON UNIVERSITY · PI BARANSKI, THOMAS JOHN, LIU, CHING-TI · 2010 to 2016
$4.6MHuman population based genetic studies to elucidate the biology of NAFLDR01DK107904 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2016 to 2020
$3.4MIdentification and functional impact of NAFLD associated genetic variantsR01DK106621 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2015 to 2019
$3.3MProbing The Dark Matter of the Genome in the NHLBI Family Heart StudyR01HL117078 · NHLBI · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2013 to 2016
$3.0MGenes of the CYP450-Derived Eicosanoids Pathway in Subclinical AtherosclerosisR01HL084099 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FORNAGE, MYRIAM · 2007 to 2010
$2.8MA Genome-Wide Association Study of Ischemic Brain Vascular InjuryR01HL093029 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FORNAGE, MYRIAM · 2009 to 2010
$1.6MGWAS of longitudinal blood pressure profiles from young adulthood to middle-ageU01HG004729 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FORNAGE, MYRIAM · 2008 to 2009
$1.1MMultidisciplinary Clinical and Translational Science (MCTS) Program (KL2)KL2TR000107 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$1.1MImplementation science to improve cardiovascular outcomes among liver transplant recipientsK23HL136891 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VANWAGNER, LISA B · 2017 to 2020
$757kNCATS NIH HHS KL2 TR000107NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004729NHLBI NIH HHS K23 HL136891NHLBI NIH HHS R01 HL084099NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL117078NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK106621NIDDK NIH HHS R01 DK107904
Abstract
The accumulation of excess fat in the liver (hepatic steatosis) in the absence of heavy alcohol consumption causes nonalcoholic fatty liver disease (NAFLD), which has become a global epidemic. Identifying metabolic risk factors that interact with the genetic risk of NAFLD is important for reducing disease burden. We tested whether serum glucose, insulin, insulin resistance, triglyceride (TG), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index (BMI), and waist-to-hip ratio adjusted for BMI interact with genetic variants in or near the patatin-like phospholipase domain containing 3 (
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