Evidence map›Paper›PMID 31334294›Full record

ArticleReports of biochemistry & molecular biology2019

Application of Multiplex Ligation-Dependent Probe Amplification in Determining the Copy Number Alterations of

Mohsen Soosanabadi, Reza Mirfakhraie, Lilit Atanesyan, Akbar Biglarian, Fatemeh Aghakhani Moghadam, Maryam Rahimi, Farkhondeh Behjati, Elaheh Keyhani

Open access · greenAbstract read
In one paragraph

Article in Reports of biochemistry & molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mohsen SoosanabadiGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Reza MirfakhraieDepartment of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Lilit AtanesyanMRC-Holland BV, Amsterdam, the Netherlands.
Akbar BiglarianDepartment of Biostatistics and Computer Sciences, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Fatemeh Aghakhani MoghadamGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Maryam RahimiGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Farkhondeh BehjatiGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Elaheh KeyhaniGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
University of Social Welfare and Rehabilitation Sciences · IRMRC Holland (Netherlands) · NLShahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to assess the usability of multiplex ligation-dependent probe amplification (MLPA) for copy number determination of

methodsClinical and immunohistochemical characteristics were assessed in 104 BC patients and the molecular subtype was determined for each tumor sample. Furthermore, HER-2/neu status was assessed by immunohistochemistry (IHC) and equivocal results were confirmed by Fluorescent in situ hybridization (FISH). The copy numbers of

resultsTwenty-five percent of all patients showed

conclusionAccording to our findings, MLPA is a fast, precise and low-cost technique to detect

Indexed as

Breast CancerCopy number variationERBB1-4IHCMLPA

Identifiers

PMID31334294
PMCPMC6590940
OpenAlexW2948179226

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.