Evidence map›Paper›PMID 31334222›Full record

ArticleFrontiers in chemistry2019

An Injectable Hyaluronic Acid-Based Composite Hydrogel by DA Click Chemistry With pH Sensitive Nanoparticle for Biomedical Application.

Xiaohong Hu, Ziyu Gao, Huaping Tan, Huiming Wang, Xincheng Mao, Juan Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaohong HuSchool of Material Engineering, Jinling Institute of Technology, Nanjing, China.
Ziyu GaoSchool of Material Engineering, Jinling Institute of Technology, Nanjing, China.
Huaping TanBiomaterials for Organogenesis Laboratory, School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, China.
Huiming WangSchool of Material Engineering, Jinling Institute of Technology, Nanjing, China.
Xincheng MaoSchool of Material Engineering, Jinling Institute of Technology, Nanjing, China.
Juan PangSchool of Material Engineering, Jinling Institute of Technology, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogels with multifunctional properties attracted intensively attention in the field of tissue engineering because of their excellent performance. Also, object-oriented design had been supposed to an effective and efficient method for material design as cell scaffold in the field of tissue engineering. Therefore, a scaffold-oriented injectable composite hydrogel was constructed by two components. One was pH-sensitive bifunctional nanoparticles for growth factor delivery to improve biofunctionability of hydrogel scaffold. The other was Diels-alder click crosslinked hyaluronic acid hydrogel as matrix. pH dependent release behavior of nanoparticle component was confirmed by results. And, its bioactivity was verified by

Indexed as

cell scaffoldDiels-alder click chemistrygrowth factor deliveryhydrogelpH-sensitive nanoparticle

Identifiers

PMID31334222
PMCPMC6617958

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.