ArticleJournal of the Korean Association of Oral and Maxillofacial Surgeons2019
Proton pump inhibitor intake negatively affects the osseointegration of dental implants: a retrospective study.
Article in Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does the use of proton pump inhibitors lead to an increased risk of dental implant failure? A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Effect of Medication Intake on Dental Implant-Related Outcomes-A Scoping Review.Clinical oral implants research · 2026Article
- Impact of proton pump inhibitors on periodontal health - A systematic review.The Saudi dental journal · 2024Review
- Early Implant Failure: A Meta-Analysis of 7 Years of Experience.Journal of clinical medicine · 2024Article
- The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2023Article
- Analyzing the Causes and Frequency of Early Dental Implant Failure among Iranians: An Epidemiological Study.International journal of dentistry · 2023Article
- The influence of proton pump inhibitors on tissue attachment around teeth and dental implants: A scoping review.Clinical and experimental dental research · 2022Article
- The effect of the use of proton pump inhibitors, serotonin uptake inhibitors, antihypertensive, and anti-inflammatory drugs on clinical outcomes of functional dental implants: A retrospective study.Clinical oral implants research · 2022Article
- Proton pump inhibitors and mandibular bone quality: A preliminary study.Dento maxillo facial radiology · 2021Article
- Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts.Bone reports · 2021Article
- Biomechanical and biochemical evaluation of the effect of systemic application of omeprazole on the osseointegration of titanium implants.International journal of implant dentistry · 2021Article
- Do proton pump inhibitors affect the biomechanical efficiency of implant?- a systematic review.Journal of oral biology and craniofacial researchReview
- Effect of proton pump inhibitors on dental implants: A systematic review and meta-analysis.Journal of Indian Prosthodontic SocietyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study sought to investigate the association between the systemic intake of proton pump inhibitors (PPI) and the early failure of dental implants. MATERIALS AND
methodsA retrospective cohort study involving 1,918 dental implants in 592 patients (69 implants in 24 PPI users and 1,849 implants in 568 nonusers, respectively) was conducted. The effect of PPI intake on the osseointegration of dental implants was evaluated using patient- and implant-level models.
resultsAmong 24 PPI users, two patients experienced implant failure, one of whom had three and the other of whom had one failed implant, respectively. Thus, the rate of failure for this population was 8.3%. Separately, 11 nonusers each experienced one implant failure, and the failure rate for these patients was 1.9%. Fisher's exact test revealed statistically significant differences between PPI users and nonusers at the implant level (
conclusionThe findings of this study suggest that PPI intake may be associated with an increased risk of early dental implant failure.
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