ReviewJournal of the Korean Association of Oral and Maxillofacial Surgeons2019
Postulated release profile of recombinant human bone morphogenetic protein-2 (rhBMP-2) from demineralized dentin matrix.
Review in Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Bone graft substitutes and dental implant stability in immediate implant surgery: a systematic review and meta-analysis.Evidence-based dentistry · 2025Pooled it
- Trial
- Dentine-derived barrier membrane versus extended platelet-rich fibrin for guided bone regeneration: a 2-year randomized clinical trial.BMC oral health · 2026Trial
- Long-Term Bone Healing Using Autogenous Tooth Bone Graft Combined with rhBMP-2 after Enucleation of a Large Odontogenic Keratocyst: A Case Report.Tissue engineering and regenerative medicine · 2026Article
- Geometry-Dependent Osteogenic Performance of Demineralized Dentin Matrix as a Carrier for rhBMP-2.Tissue engineering and regenerative medicine · 2026Article
- Geometry-Dependent Osteogenic Performance of Demineralized Dentin Matrix as a Carrier for rhBMP-2.Tissue engineering and regenerative medicine · 2026Article
- Effects of HCl concentration and immersion time on physicochemical properties, BMP-2 detection, degradation, and osteoblast response of human demineralized tooth matrix.Biomaterial investigations in dentistry · 2026Article
- Reducing Healing Period with DDM/rhBMP-2 Grafting for Early Loading in Dental Implant Surgery.Tissue engineering and regenerative medicine · 2025Article
- Bone morphogenetic protein-4 induced matrix turnover and osteogenic differentiation-related molecules of stem cells from apical papilla and its associated ALK/Smad signaling.Journal of dental sciences · 2025Article
- Review
- In Vivo Evaluation of Regenerative Osteogenic Potential Using a Human Demineralized Dentin Matrix for Dental Application.Dentistry journal · 2024Article
- Incorporating Moldable Demineralized Dentin Matrix into Treatment for a Jaw Cyst.Journal of functional biomaterials · 2023Article
- Experimental study on the biocompatibility and osteogenesis induction ability of PLLA/DDM scaffolds.Odontology · 2022Article
- Bone augmentation with autologous tooth shell in the esthetic zone for dental implant restoration: a pilot study.International journal of implant dentistry · 2021Article
- Bone regeneration of demineralized dentin matrix with platelet-rich fibrin and recombinant human bone morphogenetic protein-2 on the bone defects in rabbit calvaria.Maxillofacial plastic and reconstructive surgery · 2021Article
- Comparison of Autogenous Tooth Materials and Other Bone Grafts.Tissue engineering and regenerative medicine · 2021Review
- Dentin-Derived-Barrier Membrane in Guided Bone Regeneration: A Case Report.Materials (Basel, Switzerland) · 2021Article
- Allogeneic Dentin Graft: A Review on Its Osteoinductivity and Antigenicity.Materials (Basel, Switzerland) · 2021Review
- A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare.Journal of healthcare engineering · 2021Article
- Histological Review of Demineralized Dentin Matrix as a Carrier of rhBMP-2.Tissue engineering. Part B, Reviews · 2020Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Demineralized dentin matrix (DDM) has been used as a recombinant human bone morphogenetic protein-2 (rhBMP-2) carrier in many clinical trials. To optimize the clinical safety and efficacy of rhBMP-2 with DDM, efforts have been made to improve the delivery of rhBMP-2 by 1) lowering the administered dose, 2) localizing the protein, and 3) prolonging its retention time at the action site as well as the bone forming capacity of the carrier itself. The release profile of rhBMP-2 that is associated with endogenous BMP in dentin has been postulated according to the type of incorporation, which is attributed to the loosened interfibrillar space and nanoporous dentinal tubule pores. Physically adsorbed and modified, physically entrapped rhBMP-2 is sequentially released from the DDM surface during the early stage of implantation. As DDM degradation progresses, the loosened interfibrillar space and enlarged dentinal tubules release the entrapped rhBMP-2. Finally, the endogenous BMP in dentin is released with osteoclastic dentin resorption. According to the postulated release profile, DDM can therefore be used in a controlled manner as a sequential delivery scaffold for rhBMP-2, thus sustaining the rhBMP-2 concentration for a prolonged period due to localization. In addition, we attempted to determine how to lower the rhBMP-2 concentration to 0.2 mg/mL, which is lower than the approved 1.5 mg/mL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.