ReviewIndian dermatology online journal
Hereditary Palmoplantar Keratoderma: A Practical Approach to the Diagnosis.
Review in Indian dermatology online journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Striate palmoplantar keratoderma in a 12q13.13 microdeletion syndrome.Dermatology online journal · 2026Article
- A Spontaneous Novel c.679dupG Mutation in the LOR Gene Resulting in Loricrin Keratoderma with Ichthyosis.Dermatology practical & conceptual · 2026Article
- Sporadic Diffuse Palmoplantar Keratoderma in a Pediatric Patient With Early Onset: A Case Report.Cureus · 2025Article
- Striate palmoplantar keratoderma: a novel DSG1 mutation, combined with an LDLR mutation.Genes & genomics · 2025Article
- A case report of palmoplantar keratoderma in a 3-year-old girl: A structured approach in primary care settings.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025Article
- Atypical manifestation of psoriasis in the elderly: possible expression of Mal de Meleda diagnosis review and case report.Frontiers in medicine · 2025Article
- Molecular analysis of inherited disorders of cornification in polish patients show novel variants and functional data and provokes questions on the significance of secondary findings.Orphanet journal of rare diseases · 2024Article
- Focal acral hyperkeratosis with response to acitretin.JAAD case reports · 2024Article
- A novel FAM83G variant from palmoplantar keratoderma patient disrupts WNT signalling via loss of FAM83G-CK1α interaction.Open biology · 2024Article
- Article
- Hereditary epidermolytic palmoplantar keratosis due to a novel desmoglein-1 mutation: A case report.Clinical case reports · 2024Article
- Transgradient Variant of Mal De Meleda Presenting As Palmoplantar Keratoderma: A Case Report.Cureus · 2024Article
- Recent developments in the diagnosis, treatment, and management of Papillon-Lefèvre Syndrome.Evidence-based dentistry · 2024Article
- Connexins in epidermal health and diseases: insights into their mutations, implications, and therapeutic solutions.Frontiers in physiology · 2024Review
- Palmoplantar keratoderma, pseudo-ainhum and knuckle pads in an African patient: A case report.SAGE open medical case reports · 2023Article
- Keratoderma in Systemic Lupus Erythematosus: An Unusual Cutaneous Manifestation of Disease?Cureus · 2022Article
- Palmoplantar Keratoderma: A Molecular Genetic Analysis of Family Cases.International journal of molecular sciences · 2022Article
- Naxos Disease: The Model for Scientific Discovery.International journal of trichologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ridged skin of the palms and soles has several unique features: (i) presence of dermatoglyphics created by alternating ridges and grooves forming a unique pattern, (ii) presence of the highest density of eccrine sweat glands and absence of pilosebaceous units, and (iii) differential expression of keratins compared to the glabrous skin. These features explain the preferential localization of palmoplantar keratoderma (PPK) and several of its characteristic clinical features. PPK develops as a compensatory hyperproliferation of the epidermis and excessive production of stratum corneum in response to altered cornification of the palmoplantar skin due to mutations in the genes encoding several of the proteins involved in it. PPK can manifest as diffuse, focal, striate, or punctate forms
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.