Evidence map›Paper›PMID 31334048›Full record

ArticleInternational journal of critical illness and injury science

Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury.

Hayder M Al-Kuraishy, Ali I Al-Gareeb, Nawar R Hussien

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Article in International journal of critical illness and injury science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. A Review ofMolecules (Basel, Switzerland) · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Acute kidney injury and COVID-19.The Egyptian journal of internal medicine · 2021
    Review
  11. Article
  12. New insight into the effect of lycopene on the oxidative stress in acute kidney injury.International journal of critical illness and injury science · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hayder M Al-KuraishyDepartment of Pharmacology, Toxicology and Medicine, College of Medicine Al-Mustansiriya University, Baghdad, Iraq.
Ali I Al-GareebDepartment of Pharmacology, Toxicology and Medicine, College of Medicine Al-Mustansiriya University, Baghdad, Iraq.
Nawar R HussienDepartment of Pharmacology, Toxicology and Medicine, College of Medicine Al-Mustansiriya University, Baghdad, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the renoprotective effects of berberine and/or pentoxifylline in reduction of diclofenac-induced acute kidney injury (AKI) in rats. MATERIAL AND

methodsFifty male Sprague-Dawley rats were allocated into five groups, Group 1: Rats treated with distilled water plus normal saline for 12 days. Group 2: Rats treated with distilled water plus diclofenac for 12 days. Group 3: Rats treated with berberine plus diclofenac for 12 days. Group 4: Rats treated with pentoxifylline plus diclofenac for 12 days. Group 5: Rats treated with berberine + pentoxifylline plus diclofenac 15 mg/kg for 12 days. Blood urea, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecules (KIM-1), and cystatin-c were used to measure the severity of AKI.

resultsDiclofenac led to significant AKI by significant elevation of blood urea, serum creatinine, KIM-1, and NGAL. Treatment with berberine showed no significant effect on all biomarkers level compared to diclofenac group except on serum KIM-1 level which also seen in the pentoxifylline group whereas combination of berberine and pentoxifylline led to more significant effect in the reduction of all renal biomarkers.

conclusionCombination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced AKI.

Indexed as

Acute kidney injuryberberinediclofenacpentoxifylline

Identifiers

PMID31334048
PMCPMC6625331

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.