ArticlePlastic and reconstructive surgery. Global open2019
Hyaluronic Acid Accelerates Re-epithelialization and Alters Protein Expression in a Human Wound Model.
Article in Plastic and reconstructive surgery. Global open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04865952 (Effect of Hyaluronic Acid Application in Gene Expression and Cellular Behavior 24-hours After Injury), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Hyaluronic Acid Application in Gene Expression and Cellular Behavior 24-hours After Injury
Who cites it
36 citing papers in PubMed, 65 citations in OpenAlex.
- Effect of Hyaluronic Acid on Palatal Wound Healing-A Randomized Crossover Clinical Trial.Clinical oral implants research · 2026Trial
- Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on postoperative morbidity in palatal donor area: a randomized controlled clinical trial.Clinical oral investigations · 2023Trial
- Anal HPV in Kidney Transplant Recipients: A Closer Look at Pathogenesis and Clinical Management.Pathogens (Basel, Switzerland) · 2026Review
- Effect of Probiotic Limosilactobacillus reuteri and Hyaluronic Acid Gel Combination Therapy on Neutrophil Response, Neovascularization, and Reepithelialization in the Wound-Healing Process Following Tooth Extraction: An In Vivo Study.European journal of dentistry · 2026Article
- Investigation of multifaceted wound healing effect of exopolysaccharide (EPS) produced from probiotic strain Lactiplantibacillus plantarum GD2 as in vitro and in ovo.Scientific reports · 2025Article
- Review
- Oral Treatment with EGCG, Folic Acid, Vitamin B12, and Hyaluronic Acid Improves HPV Clearance and Counteracts Its Persistence: A Clinical Study.International journal of molecular sciences · 2025Article
- Polysaccharides and Peptides With Wound Healing Activity From Bacteria and Fungi.Journal of basic microbiology · 2024Review
- A Biologic and Physical Characterization of an Injectable Amniotic Membrane Designed for Treating Diabetic Foot Ulcers.Bioengineering (Basel, Switzerland) · 2024Article
- Incorporation of natural and synthetic polymers into honey hydrogel for wound healing: A review.Health science reports · 2024Article
- Counteracting HPV Cervical and Anal Infection through Dietary Supplementation of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid: Clinical Case Reports.Journal of clinical medicine · 2024Article
- Effect of Hyaluronic Acid Mucoadhesives on Palatal Wound Healing and Postoperative Discomfort in Free Gingival Graft Surgery: A Clinical Trial.Frontiers in dentistry · 2024Article
- Evaluation of enteral and parenteral hyaluronic acid in induced ischemic skin flaps in rats: a double-blinded and randomized study.Acta cirurgica brasileira · 2024Article
- A novelFrontiers in microbiology · 2024Article
- Factors affecting the healing of decubital lesions in patients wearing newly made dentures.Journal of dental sciences · 2024Article
- Modern Approaches in Wounds Management.Polymers · 2023Review
- A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence.Cell reports. Medicine · 2023Article
- New Smart Bioactive and Biomimetic Chitosan-Based Hydrogels for Wounds Care Management.Pharmaceutics · 2023Article
- A fabricated hydrogel of hyaluronic acid/curcumin shows super-activity to heal the bacterial infected wound.AMB Express · 2023Article
- Preventing Persistence of HPV Infection with Natural Molecules.Pathogens (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyaluronic acid (HA), a large glycosaminoglycan involved in proliferation, migration, and tissue repair, is suggested to be an important factor for keratinocyte activation and re-epithelialization. The experimental hypothesis of this study was that HA accelerates re-epithelialization, and we aimed to investigate the effect of exogenous intradermal HA during deep dermal, incisional wound healing in vivo in humans, the primary endpoint being re-epithelialization.
methodsA total of 8 standardized deep dermal incisional wounds (depth 1.6 mm, width 1.8 mm) per subject were induced in 10 healthy volunteers. Two of the wound sites per subject were pretreated with injections of HA and 2 with saline solution. At 2 time points (24 hours and 14 days), 2 biopsies for each treatment group (one for histology and one for proteomics) were taken. Skin erythema was measured at 24-hour intervals for 14 days as a surrogate measurement of inflammation.
resultsAt 24 hours, 8 of 9 wounds pretreated with HA showed complete re-epithelization, whereas none of the wounds pretreated with saline had re-epithelized. Wounds pretreated with HA also showed a 10-fold regulation of 8 identified proteins involved in wound healing compared to wounds treated with saline solution. No difference in inflammation, as measured as erythema, could be seen between any of the groups.
conclusionsWe conclude that HA accelerates re-epithelialization and stimulates an altered protein expression
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.