ArticlePlastic and reconstructive surgery. Global open2019
The Role of Fat Grafting in Alleviating Neuropathic Pain: A Critical Review of the Literature.
Article in Plastic and reconstructive surgery. Global open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Postmastectomy Breast Reconstruction in Patients with Non-Metastatic Breast Cancer: An Ontario Health (Cancer Care Ontario) Clinical Practice Guideline.Current oncology (Toronto, Ont.) · 2025Guideline
- The Efficacy of Fat Grafting on Treating Post-Mastectomy Pain with and without Breast Reconstruction: A Systematic Review and Meta-Analysis.Current oncology (Toronto, Ont.) · 2024Pooled it
- The Effect of Fat Grafting on Scars Hyperpigmentation: A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2024Pooled it
- Outcomes in Hybrid Breast Reconstruction: A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Cell therapies for chondral defects of the talus: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Optimization of fat grafting to attenuate radiation damage: a narrative review.Gland surgery · 2026Review
- Effectiveness of Lipofilling in Postmastectomy Pain Syndrome: A Prospective Cohort Study.Plastic surgery (Oakville, Ont.) · 2026Article
- Review
- Integrative Migraine Therapy: From Current Concepts to Future Directions-A Plastic Surgeon's Perspective.Medicina (Kaunas, Lithuania) · 2025Review
- Preserved fascicular architecture predicts neuroma pain: a morphometric study.Acta neuropathologica communications · 2025Article
- Surgical Outcomes in Non-Transected and Partially Transected Peripheral Nerve Injuries.Brain sciences · 2025Review
- From Transplant to Reamputation: A Case Report on Chronic Rejection and Innovative Treatment in Hand Allotransplantation.Plastic and reconstructive surgery. Global open · 2025Article
- Free fat flap transfer in recurrent neurogenic thoracic outlet syndrome pain treatment: FIRST observational pilot study.International journal of surgery protocols · 2025Article
- Diagnosis and Management of Neuropathic Breast Pain.Plastic and reconstructive surgery. Global open · 2024Article
- Secondary Trigger Point Deactivation Surgery for Nerve Compression Headaches: A Scoping Review.Plastic and reconstructive surgery. Global open · 2024Article
- Autologous Fat Grafting for Post-mastectomy Pain Syndrome: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- Comparative Analysis of a New Automatic System and Four Existing Techniques for Autologous Fat Grafting.Plastic and reconstructive surgery. Global open · 2023Article
- Autologous Fat Grafting Restores Soft-tissue Contour Deformities after Vascular Anomaly: Widening the Horizons of Employment of Autologous Fat Grafting.Plastic and reconstructive surgery. Global open · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuropathic pain is one of the more severe types of chronic pain and presents a great challenge as response to medical therapy remains often unpredictable. With the opioid epidemic and the search for ways to avoid narcotics, physicians are seeking other modalities to treat neuropathic pain. In recent years, surgeons have explored various surgical avenues to improve outcomes. The aim of this review was to evaluate the current clinical evidence regarding the efficacy of fat grafting for the treatment of neuropathic pain.
methodsA critical review was conducted to examine the current clinical evidence of fat grafting as a therapy for neuropathic pain caused by neuromas, peripheral neuralgia, migraine and headaches, neuropathic scar pain, and postmastectomy pain syndrome.
resultsThe precise mechanism role of fat grafting in modulating neuropathic pain remains unclear, but it appears to reduce pain levels through the anti-inflammatory effects of adipose-derived stem cells and mechanical cushioning by fat.
conclusionsFat grafting is an emerging therapy for chronic neuropathic pain of various etiologies. Although promising results have been reported, sample size and level of evidence of current studies are low. The encouraging results, however, are worthy of further clinical and scientific study. The minimally invasive nature of fat grafting and favorable risk profile make this an attractive therapy for neuropathic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.