ArticlePlastic and reconstructive surgery. Global open2019
Acellular Dermal Matrix Reduces Myofibroblast Presence in the Breast Capsule.
Article in Plastic and reconstructive surgery. Global open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Histological Analyses of Capsular Contracture and Associated Risk Factors: A Systematic Review.Aesthetic plastic surgery · 2021Pooled it
- Efficacy of Acellular Dermal Matrix in Capsular Contracture of Implant-Based Breast Reconstruction: A Single-Arm Meta-analysis.Aesthetic plastic surgery · 2020Pooled it
- The Effects of Ovine-Derived Reinforced Tissue Matrix Surrounding Silicone-Based Implants in a Rat Prepectoral Reconstruction Model.Bioengineering (Basel, Switzerland) · 2026Article
- Breast Cancer Hormone Therapy Modulates Breast Implant Capsular Contracture.Plastic and reconstructive surgery. Global open · 2025Article
- Revisiting low complications of VICRYL mesh in breast reconstruction: Insights from an updated systematic review.JPRAS open · 2025Review
- A Histological Assessment Tool for Breast Implant Capsules Validated in 480 Patients with and Without Capsular Contracture.Aesthetic plastic surgery · 2025Article
- Capsular Contracture After Postmastectomy Radiation in Implant-Based Breast Reconstruction: Effect of Implant Pocket and Two-Stage Surgery.Journal of breast cancer · 2024Article
- Comparing Cortiva Silhouette to AlloDerm for Use in Prepectoral Two-stage Prosthetic Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2024Article
- A Comparison of Capsular Contracture Rates after Immediate Implant-based Breast Reconstruction Using Biologic versus Synthetic Mesh.Plastic and reconstructive surgery. Global open · 2024Article
- Extracellular Matrices as Bioactive Materials for In Situ Tissue Regeneration.Pharmaceutics · 2023Review
- How Porcine Acellular Dermal Matrix Influences the Development of the Breast Capsule 1 Year after Implantation: A Histopathological Analysis.Plastic and reconstructive surgery. Global open · 2023Article
- Single Stitch Vicryl Mesh Wrap for Prepectoral Implant Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2023Article
- Implantation and tracing of green fluorescent protein-expressing adipose-derived stem cells in peri-implant capsular fibrosis.Stem cell research & therapy · 2023Article
- Human-Mimic Submuscular and Premuscular Irradiated Rat Model: Histologic Characteristics of the Capsule Tissue in Contact with the Breast Implant.The breast journal · 2023Article
- Human Acellular Dermal Matrix in Reconstructive Surgery-A Review.Biomedicines · 2022Review
- Biological Cover Mitigates Disruption of the Dermal Structure in Mechanically Expanded Skin in a Porcine Model.International journal of molecular sciences · 2022Article
- Submuscular Implant-Based Breast Reconstruction Using a Musculofascial Pocket Formed by the Pectoralis Major Muscle and the Serratus Anterior Muscle Fascia: A Novel Surgical Approach.World journal of surgery · 2022Article
- Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices.Tissue engineering and regenerative medicine · 2022Article
- BraxonFrontiers in surgery · 2022Review
- Current Concepts in Capsular Contracture: Pathophysiology, Prevention, and Management.Seminars in plastic surgery · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCapsular contracture remains a common complication after implant-based breast reconstruction. Previous work has suggested that the use of acellular dermal matrix (ADM) reduces the rate of capsular contracture, though little is understood about the underlying mechanism. As myofibroblasts are believed to be the key cells implicated in contracture formation, we hypothesized that ADM would result in a reduction in periprosthetic myofibroblast concentration.
methodsFive patients who underwent immediate prepectoral tissue expander placement with anterior ADM coverage and an inferior cuff were included. At the second stage, tissue samples were obtained of both ADM and capsule from each reconstructed breast. Samples were then prepared for hematoxylin and eosin staining and immunohistochemistry for myofibroblast identification (alpha smooth muscle actin and vimentin positive and desmin negative) and analysis. Experimental values are presented as mean ± SD unless otherwise stated. Statistical significance was determined using unpaired
resultsSuccessful incorporation of ADM was noted in all cases. A significant reduction in myofibroblast concentration was noted in the ADM versus the capsule (
conclusionsIn the presence of ADM, there are significantly fewer myofibroblasts in breast capsules and thinner capsules on histology. Given the central role of myofibroblasts in the development of clinically significant capsular contracture, this study unmasks a possible mechanism for the protective effect of ADM with respect to capsular contracture development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.