Evidence map›Paper›PMID 31333695›Full record

ArticleFrontiers in plant science2019

Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus

Madeleine Ernst, Louis-Félix Nothias, Justin J J van der Hooft, Ricardo R Silva, C Haris Saslis-Lagoudakis, Olwen M Grace, Karen Martinez-Swatson, Gustavo Hassemer, Luís A Funez, Henrik T Simonsen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 50 citations in OpenAlex.

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  7. Microbial Metabolites Annotation by Mass Spectrometry-Based Metabolomics.Advances in experimental medicine and biology · 2023
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  8. Review
  9. Gene discovery and virus-induced gene silencing reveal branched pathways to major classes of bioactive diterpenoids inProceedings of the National Academy of Sciences of the United States of America · 2022
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  10. Euphocactoside, a New Megastigmane Glycoside fromPlants (Basel, Switzerland) · 2022
    Article
  11. Article
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  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
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  19. Article
  20. In Vitro Modulation of P-Glycoprotein Activity byPharmaceuticals (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 5 countries.

Madeleine ErnstNatural History Museum of Denmark, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Louis-Félix NothiasCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States.
Justin J J van der HooftBioinformatics Group, Department of Plant Sciences, Wageningen University & Research, Wageningen, Netherlands.
Ricardo R SilvaCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States.
C Haris Saslis-LagoudakisNatural History Museum of Denmark, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Olwen M GraceComparative Plant and Fungal Biology, Royal Botanic Gardens, Richmond, United Kingdom.
Karen Martinez-SwatsonNatural History Museum of Denmark, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Gustavo HassemerNatural History Museum of Denmark, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Luís A FunezDepartment of Botany, Federal University of Santa Catarina, Florianópolis, Brazil.
Henrik T SimonsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Marnix H MedemaBioinformatics Group, Department of Plant Sciences, Wageningen University & Research, Wageningen, Netherlands.
Dan StaerkDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Niclas NilssonFront End Innovation, LEO Pharma A/S, Ballerup, Denmark.
Paola LovatoFront End Innovation, LEO Pharma A/S, Ballerup, Denmark.
Pieter C DorresteinCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States.
Nina RønstedNatural History Museum of Denmark, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
University of California, San Diego · USUniversity of Copenhagen · DKLeo Pharma (Denmark) · DKNatural History Museum Aarhus · DKUniversidade Federal de Santa Catarina · BRWageningen University & Research · NLRoyal Botanic Gardens, Kew · GBTechnical University of Denmark · DK

Funding

TrainingP41GM103484 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PEVZNER, PAVEL A · 2012 to 2018
$8.7M
Unified Computation Tools for Natural Products ResearchR01GM107550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COTTRELL, GARRISON W, GERWICK, WILLIAM HENRY · 2013 to 2025
$8.2M
Reuse of Public Metabolomics DataR03CA211211 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DORRESTEIN, PIETER C · 2016 to 2016
$155k
NCI NIH HHS R03 CA211211NIGMS NIH HHS P41 GM103484NIGMS NIH HHS R01 GM107550
6 · The paper itself

Abstract

Coevolutionary theory suggests that an arms race between plants and herbivores yields increased plant specialized metabolite diversity and the geographic mosaic theory of coevolution predicts that coevolutionary interactions vary across geographic scales. Consequently, plant specialized metabolite diversity is expected to be highest in coevolutionary hotspots, geographic regions, which exhibit strong reciprocal selection on the interacting species. Despite being well-established theoretical frameworks, technical limitations have precluded rigorous hypothesis testing. Here we aim at understanding how geographic separation over evolutionary time may have impacted chemical differentiation in the cosmopolitan plant genus

Indexed as

coevolutioncomputational metabolomicsEuphorbiaimmunomodulatory testingspecialized metabolites

Identifiers

PMID31333695
PMCPMC6615404
OpenAlexW2950939422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.