Evidence map›Paper›PMID 31333680›Full record

Trial reportFrontiers in immunology2019

Allogeneic HSCT for Autoimmune Diseases: A Retrospective Study From the EBMT ADWP, IEWP, and PDWP Working Parties.

Raffaella Greco, Myriam Labopin, Manuela Badoglio, Paul Veys, Juliana M Furtado Silva, Mario Abinun, Francesca Gualandi, Martin Bornhauser, Fabio Ciceri, Riccardo Saccardi and 6 more

Registry-linked trialOpen access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06986382 (Phase 1b/2a Trial of Allogeneic Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06986382 phase1 / phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Phase 1b/2a Trial of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset (EO), Medically Refractory (MR) Crohn Disease (CD)

TypeinterventionalSponsorStanford UniversityRan2025 to 2040Enrolled14ConditionsCrohn DiseaseArmsCliniMACS® TCR α/β Reagent Kit and CliniMACS® CD19 System, Prednisone/Methylprenisolone, Palifermin, ATG, Clofarabine
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Hyperacute Graft-Versus-Host Disease.Bone marrow transplantation · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. The EBMT-ADWP and the CIBMTR.Handbook of clinical neurology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 7 countries.

Raffaella GrecoUnit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Myriam LabopinEBMT Paris Study Office/CEREST-TC - Department of Haematology, Saint Antoine Hospital - INSERM UMR 938 - Université Pierre et Marie Curie, Paris, France.
Manuela BadoglioEBMT Paris Study Office/CEREST-TC - Department of Haematology, Saint Antoine Hospital - INSERM UMR 938 - Université Pierre et Marie Curie, Paris, France.
Paul VeysDepartment of Bone Marrow Transplantation, Great Ormond Street Hospital, London, United Kingdom.
Juliana M Furtado SilvaDepartment of Bone Marrow Transplantation, Great Ormond Street Hospital, London, United Kingdom.
Mario AbinunGreat North Childrens' Hospital, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Francesca GualandiDivisione Ematologia e Trapianto di Midollo, IRCCS AOU San Martino-IST, Genova, Italy.
Martin BornhauserMedizinische Klinik und Poliklinik I, Carl Gustav Carus University Hospital, Dresden, Germany.
Fabio CiceriUnit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Riccardo SaccardiDepartment of Haematology, Careggi University Hospital, Florence, Italy.
Arjan LankesterIEWP-EBMT Chair: Department of Pediatrics, University Medical Centre, Leiden, Netherlands.
Tobias AlexanderDepartment of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany.
Andrew R GenneryGreat North Childrens' Hospital, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Peter BaderPDWP-EBMT Chair; Division for SCT and Immunology, Department for Children and Adolescents, Frankfurt, Germany.
Dominique FargeUnité de Médecine Interne: Maladies Auto-immunes et Pathologie Vasculaire (UF 04), Hôpital St-Louis, AP-HP, Paris, France.
John A SnowdenADWP-EBMT Chair; Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
Great North Children's Hospital · GBGreat Ormond Street Hospital · GBInserm · FRVita-Salute San Raffaele University · ITAzienda Ospedaliero-Universitaria Careggi · ITCharité - Universitätsmedizin Berlin · DEDélégation Paris 7 · FREuropean Society for Blood and Marrow Transplantation · NLOspedale Policlinico San Martino · ITSheffield Teaching Hospitals NHS Foundation Trust · GBUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Autoimmune DiseasesGraft vs Host DiseaseHematopoietic Stem Cell TransplantationTransplantation ConditioningAcute DiseaseAdolescentAdultAge FactorsAllograftsChildChild, PreschoolFemaleHumansIncidenceInfantMaleallogeneic hematopoietic stem cell transplantationautoimmune diseaseshematological autoimmune diseaseslong-term outcomenon-hematological autoimmune diseases

Identifiers

PMID31333680
PMCPMC6622152
OpenAlexW2953891548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.