Evidence map›Paper›PMID 31333666›Full record

Trial reportFrontiers in immunology2019

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.

Laura A Ridgley, Amy E Anderson, Nicola J Maney, Najib Naamane, Andrew J Skelton, Catherine A Lawson, Paul Emery, John D Isaacs, Ruaidhrí J Carmody, Arthur G Pratt

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. CD4European journal of immunology · 2026
    Article
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  6. Observational
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  9. Classical Signaling and Trans-Signaling Pathways Stimulated byInternational journal of molecular sciences · 2022
    Article
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  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Laura A RidgleyInstitute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.
Amy E AndersonInstitute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.
Nicola J ManeyInstitute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.
Najib NaamaneInstitute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.
Andrew J SkeltonInstitute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.
Catherine A LawsonLeeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, University of Leeds, Leeds, United Kingdom.
Paul EmeryLeeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, University of Leeds, Leeds, United Kingdom.
John D IsaacsInstitute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.
Ruaidhrí J CarmodyInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Arthur G PrattInstitute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.
Newcastle University · GBLeeds Teaching Hospitals NHS Trust · GBUniversity of Glasgow · GBUniversity of Leeds · GB

Funding

Arthritis Research UKBritish Medical AssociationMedical Research Council MR/P020941/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, ImmunologicalAdultAgedAged, 80 and overArthritis, RheumatoidCD4-Positive T-LymphocytesFemaleHumansInterleukin-6MaleMiddle AgedReceptors, Antigen, T-CellSignal TransductionSTAT3 Transcription FactorTranscription, GeneticIL6 protein, humanInterleukin-6Receptors, Antigen, T-CellSTAT3 protein, humanSTAT3 Transcription FactorCD4+ T cellearly rheumatoid arthritisinterleukin-6pathogenesistranscriptional programming

Identifiers

PMID31333666
PMCPMC6618050
OpenAlexW2953411401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.