Evidence map›Paper›PMID 31333644›Full record

ReviewFrontiers in immunology2019

Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity.

Thayer K Darling, Tracey J Lamb

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 262 citations in OpenAlex.

  1. Review
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  10. Review
  11. Autophagy activation by the Becn1Brain, behavior, and immunity · 2026
    Article
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  18. Review
  19. Article
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Thayer K DarlingImmunology and Molecular Pathogenesis Program, Emory University Laney Graduate School, Atlanta, GA, United States.
Tracey J LambDepartment of Pathology, University of Utah, Salt Lake City, UT, United States.
University of Utah · US

Funding

TRAINING IN IMMUNOLOGY AND MOLECULAR PATHOGENESIST32AI007610 · NIAID · EMORY UNIVERSITY · PI EVAVOLD, BRIAN D · 2000 to 2014
$4.4M
Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
EphA2 mediates opening of the blood brain barrier in cerebral malariaR01NS097819 · NINDS · UNIVERSITY OF UTAH · PI LAMB, TRACEY JANE · 2017 to 2021
$1.8M
Ephrin ligands as novel targets for an adjunct therapy in cerebral malariaR21NS085382 · NINDS · EMORY UNIVERSITY · PI LAMB, TRACEY JANE · 2014 to 2015
$437k
The Role of EphA2 in the Development of Cerebral MalariaF31NS098736 · NINDS · EMORY UNIVERSITY · PI KING, THAYER PATRICE · 2016 to 2018
$132k
NIAID NIH HHS T32 AI007610NIAID NIH HHS T32 AI106699NINDS NIH HHS F31 NS098736NINDS NIH HHS R01 NS097819NINDS NIH HHS R21 NS085382
6 · The paper itself

Abstract

Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands. The ubiquitous expression of Eph receptors and ephrin ligands among the cellular players of the immune system underscores the importance of these molecules in orchestrating an optimal immune response. This review provides an overview of the various roles of Eph receptors and ephrin ligands in immune cell development, activation, and migration. We also discuss the role of Eph receptors in disease pathogenesis as well as the implications of Eph receptors as future immunotherapy targets. Given the diverse and critical roles of Eph receptors and ephrin ligands throughout the immune system during both resting and activated states, this review aims to highlight the critical yet underappreciated roles of this family of signaling molecules in the immune system.

Indexed as

AnimalsCell AdhesionCell DifferentiationCell MovementEphrinsHumansLigandsProtein BindingReceptors, Eph FamilySignal TransductionEphrinsLigandsReceptors, Eph Familyactivationadhesioncell traffickingdiseaseEphephrininflammationmigration

Identifiers

PMID31333644
PMCPMC6620610
OpenAlexW2949592035

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.