Evidence map›Paper›PMID 31333507›Full record

ArticleFrontiers in psychiatry2019

A Personalized Autism Diagnosis CAD System Using a Fusion of Structural MRI and Resting-State Functional MRI Data.

Omar Dekhil, Mohamed Ali, Yaser El-Nakieb, Ahmed Shalaby, Ahmed Soliman, Andrew Switala, Ali Mahmoud, Mohammed Ghazal, Hassan Hajjdiab, Manuel F Casanova and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Attention-Enhanced Fusion of Structural and Functional MRI for Analyzing HIV-Associated Asymptomatic Neurocognitive Impairment.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review of Progress in Diagnostic Studies of Autism Spectrum Disorder Using Neuroimaging.Interdisciplinary sciences, computational life sciences · 2023
    Review
  11. Article
  12. The Role of Structure MRI in Diagnosing Autism.Diagnostics (Basel, Switzerland) · 2022
    Article
  13. Article
  14. Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Omar DekhilBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Mohamed AliBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Yaser El-NakiebBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Ahmed ShalabyBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Ahmed SolimanBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Andrew SwitalaBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Ali MahmoudBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Mohammed GhazalBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Hassan HajjdiabDepartment of Electrical and Computer Engineering, Abu Dhabi University, Abu Dhabi, United Arab Emirates.
Manuel F CasanovaDepartment of Biomedical Sciences, University of South Carolina, Greenville, SC, United States.
Adel ElmaghrabyComputer Engineering and Computer Science Department, University of Louisville, Louisville, KY, United States.
Robert KeyntonBioengineering Department, University of Louisville, Louisville, KY, United States.
Ayman El-BazBioimaging Lab, Bioengineering Department, University of Louisville, Louisville, KY, United States.
Gregory BarnesDepartment of Neurology, University of Louisville, Louisville, KY, United States.
University of Louisville · USAbu Dhabi University · AEUniversity of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder is a neuro-developmental disorder that affects the social abilities of the patients. Yet, the gold standard of autism diagnosis is the autism diagnostic observation schedule (ADOS). In this study, we are implementing a computer-aided diagnosis system that utilizes structural MRI (sMRI) and resting-state functional MRI (fMRI) to demonstrate that both anatomical abnormalities and functional connectivity abnormalities have high prediction ability of autism. The proposed system studies how the anatomical and functional connectivity metrics provide an overall diagnosis of whether the subject is autistic or not and are correlated with ADOS scores. The system provides a personalized report per subject to show what areas are more affected by autism-related impairment. Our system achieved accuracies of 75% when using fMRI data only, 79% when using sMRI data only, and 81% when fusing both together. Such a system achieves an important next step towards delineating the neurocircuits responsible for the autism diagnosis and hence may provide better options for physicians in devising personalized treatment plans.

Indexed as

autismComputer-Added Diagnostics (CAD) systemsfunctional magnetic resonance imagingmachine learningpersonalized diagnosisstructural magnetic resonance imaging

Identifiers

PMID31333507
PMCPMC6620533
OpenAlexW2955994503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.