ArticleFrontiers in physiology2019
Retinal Endothelial Function, Physical Fitness and Cardiovascular Risk: A Diagnostic Challenge.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02796976 (Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population (ExAMIN AGE)
Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Advancing Retinal Vessel Analysis: Reproducibility of Myogenic Constriction and Assessment of Regulatory Capacity.Translational vision science & technology · 2026Article
- Effects of Exercise Mode and Intensity on Retinal Microvascular Structure and Function in Heart Failure Patients with Preserved Ejection Fraction: A Pilot Exercise Intervention Trial.Journal of vascular research · 2026Article
- Quantitative Comparison of a Handheld and a Table-Top Fundus Camera for Retinal Microvascular Assessment.Reports (MDPI) · 2026Article
- Four Months of Exercise Intervention Improved Visuomotor, Functional and Cardiorespiratory Capacity in a Patient with Metastatic Uveal Melanoma.Reports (MDPI) · 2025Article
- Device-based day-to-day and observer variability to quantify dilation capacity in the retinal microcirculation.Frontiers in physiology · 2025Article
- Non-Invasive Retinal Vessel Analysis as a Predictor for Cardiovascular Disease.Journal of personalized medicine · 2024Review
- Dynamic retinal vessel analysis: flickering a light into the brain.Frontiers in aging neuroscience · 2024Review
- Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study.Frontiers in medicine · 2022Article
- Neuro-vascular coupling and heart rate variability in patients with type II diabetes at different stages of diabetic retinopathy.Frontiers in medicine · 2022Article
- Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk.Scientific reports · 2021Article
- Quantification of Retinal Vessel Myogenic Constriction in Response to Blood Pressure Peaks: Implications for Flicker Light-Induced Dilatation.Frontiers in physiology · 2021Article
- Microvascular function in non-dippers: Potential involvement of the salt sensitivity biomarker, marinobufagenin-The African-PREDICT study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDynamic retinal vessel analysis (DVA) is a new non-invasive method to quantify microvascular endothelial dysfunction by flicker light-induced dilatation (FID). FID has been shown to be impaired in type 2 diabetes as well as heart failure. The aim of the study was to analyze FID in healthy active versus healthy sedentary and cardiovascular (CV) risk patients in addition to corresponding static vessel diameters.
methodsThirty-one healthy active (HA, mean age 60 ± 8 years), 33 healthy sedentary individuals (HS, 59 ± 7 years) and 76 sedentary patients with increased CV risk (SR, 58 ± 6 years) were included in this cross-sectional study. Group differences in CV risk factors and cardiorespiratory fitness, maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the arteriolar (AFarea) and venular (VFarea) area under the flicker curve were analyzed. The central retinal arteriolar and venular diameters were used to calculate the arteriolar-to-venular diameter ratio (AVR).
resultsHS [ADmax = 3.5 (2.1)%; AFarea = 48.2 (31.9)% DISCUSSION: FID can differentiate between sedentary low and high risk individuals. However, FID in healthy active persons (HA) seemed impaired with a concomitant higher AVR. We postulate that lower FID in HA may be explained by predilatated arterioles and a reduced dilatation reserve. We recommend combination of FID with analysis of retinal vessel diameters to differentiate functional non-responders from manifest microvascular endothelial dysfunction and, thereby, improve microvascular risk stratification in a personalized medicine approach. CLINICAL
trial registrationClinicalTrials.gov: NCT02796976 (https://clinicaltrials.gov/ ct2/show/NCT02796976).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.