Evidence map›Paper›PMID 31333447›Full record

ArticleFrontiers in pharmacology2019

Anti-Inflammatory and Anti-Arthritic Efficacies of an Indian Traditional Herbo-Mineral Medicine "Divya Amvatari Ras" in Collagen Antibody-Induced Arthritis (CAIA) Mouse Model Through Modulation of IL-6/IL-1β/TNF-α/NFκB Signaling.

Acharya Balkrishna, Sachin Shridhar Sakat, Kheemraj Joshi, Sandeep Paudel, Deepika Joshi, Kamal Joshi, Ravikant Ranjan, Abhishek Gupta, Kunal Bhattacharya, Anurag Varshney

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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  11. Therapeutic Effects ofFood science of animal resources · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Acharya BalkrishnaDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Sachin Shridhar SakatDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Kheemraj JoshiDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Sandeep PaudelDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Deepika JoshiDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Kamal JoshiDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Ravikant RanjanDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Abhishek GuptaDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Kunal BhattacharyaDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Anurag VarshneyDrug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
Patanjali Research Foundation · INHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is defined as a chronic autoimmune inflammatory disorder that causes damage to limb joints and progressive injuries to secondary organs. Medical practitioners prescribe Methotrexate (MTX) as standard care medicine for treating RA. However, the long-term application of MTX has shown to have adverse health-related effects. Divya Amvatari Ras (DAR), an Indian Ayurvedic herbo-mineral formulation, has been described in ancient texts to provide relief from RA inflammation associated distress. Therefore, in the present study, we explored the biocompatibility, anti-inflammatory, and anti-arthritic efficacy of DAR using

Indexed as

AyurvedacytokinesDivya Amvatari Rasherbo-mineral formulationinflammationin vivo studiesrheumatoid arthritis

Identifiers

PMID31333447
PMCPMC6614787
OpenAlexW2953954814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.