Evidence map›Paper›PMID 31333444›Full record

ArticleFrontiers in aging neuroscience2019

Cerebral Blood Flow in Community-Based Older Twins Is Moderately Heritable: An Arterial Spin Labeling Perfusion Imaging Study.

Jiyang Jiang, Anbupalam Thalamuthu, Forrest C Koch, Tao Liu, Qun Xu, Julian N Trollor, David Ames, Margaret J Wright, Vibeke Catts, Perminder S Sachdev and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Jiyang JiangCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
Forrest C KochCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
Tao LiuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
Qun XuDepartment of Health Manage Centre, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Julian N TrollorCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
David AmesNational Ageing Research Institute, University of Melbourne, Parkville, VIC, Australia.
Margaret J WrightNeuroImaging Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Vibeke CattsCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
Wei WenCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
UNSW Sydney · AUPrince of Wales Hospital · AUBeihang University · CNQIMR Berghofer Medical Research Institute · AURenji Hospital · CNUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adequate cerebral blood flow (CBF) is necessary to maintain brain metabolism and function. Arterial spin labeling (ASL) is an emerging MRI technique offering a non-invasive and reliable quantification of CBF. The genetic basis of CBF has not been well documented, and one approach to investigate this is to examine its heritability. The current study aimed to examine the heritability of CBF using ASL data from a cohort of community-dwelling older twins (41 monozygotic (MZ) and 25 dizygotic (DZ) twin pairs; age range, 65-93 years; 56.4% female). The results showed that the cortex had higher CBF than subcortical gray matter (GM) regions, and CBF in the GM regions of the anterior cerebral artery (ACA) territory was lower than that of the middle (MCA) and posterior (PCA) cerebral arteries. After accounting for the effects of age, sex and scanner, moderate heritability was identified for global CBF (

Indexed as

agingcerebral blood flowcommunity-dwellingheritabilitytwin study

Identifiers

PMID31333444
PMCPMC6615405
OpenAlexW2952674663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.