ArticleFrontiers in human neuroscience2019
Applying a Women's Health Lens to the Study of the Aging Brain.
Article in Frontiers in human neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- Comparison of Health, Quality of Life, and Psychological and Cognitive Function Between Perimenopausal and Postmenopausal Women: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Younger adult women who had a stroke or at high stroke risk: Exploration of their experiences and needs.Qualitative research in medicine & healthcare · 2025Article
- The proportion of plant-based food consumption during midlife and cognitive health in later life in Australian women: data from the Women's Healthy Ageing Project (WHAP).European journal of nutrition · 2025Article
- The Influence of Sex and Sex-Steroid Hormones on Cerebellar Structure and Functional Connectivity Across Adulthood.Human brain mapping · 2025Article
- Cognitive strategy in verbal fluency: sex differences, menstrual cycle, and menopause effects.Cognitive processing · 2025Article
- Considering the interconnected nature of social identities in neuroimaging research.Nature neuroscience · 2025Review
- The Role of Estrogen in Brain MicroRNAs Regulation.Advanced pharmaceutical bulletin · 2024Review
- Linking menopause-related factors, history of depression, APOE ε4, and proxies of biological aging in the UK biobank cohort.Hormones and behavior · 2024Article
- Functional brain networks are associated with both sex and gender in children.Science advances · 2024Article
- Previous pregnancies might mitigate cortical brain differences associated with surgical menopause.Human brain mapping · 2024Article
- Menopause Status and Within-Group Differences in Chronological Age Affect the Functional Neural Correlates of Spatial Context Memory in Middle-Aged Females.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- New Frontiers for the Understanding of Aging: The Power and Possibilities of Studying the Cerebellum.Current opinion in behavioral sciences · 2023Article
- Functional brain networks are associated with both sex and gender in children.bioRxiv : the preprint server for biology · 2023Article
- Why and How to Account for Sex and Gender in Brain and Behavioral Research.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Carotid intima media thickness and white matter hyperintensity volume among midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Article
- Hormonal contraception and risk for cognitive impairment or Alzheimer's disease and related dementias in young women: a scoping review of the evidence.Frontiers in global women's health · 2023Article
- Network segregation in aging females and evaluation of the impact of sex steroid hormones.Frontiers in human neuroscience · 2023Article
- Age-volume associations in cerebellar lobules by sex and reproductive stage.Brain structure & function · 2022Article
- Sex- and age-specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort.Human brain mapping · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major challenge in neuroscience is to understand what happens to a brain as it ages. Such insights could make it possible to distinguish between individuals who will undergo typical aging and those at risk for neurodegenerative disease. Over the last quarter century, thousands of human brain imaging studies have probed the neural basis of age-related cognitive decline. "Aging" studies generally enroll adults over the age of 65, a historical precedent rooted in the average age of retirement. A consequence of this research tradition is that it overlooks one of the most significant neuroendocrine changes in a woman's life: the transition to menopause. The menopausal transition is marked by an overall decline in ovarian sex steroid production-up to 90% in the case of estradiol-a dramatic endocrine change that impacts multiple biological systems, including the brain. Despite sex differences in the risk for dementia, the influence that biological sex and sex hormones have on the aging brain is historically understudied, leaving a critical gap in our understanding of the aging process. In this
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.