Evidence map›Paper›PMID 31333403›Full record

ArticleFrontiers in neuroscience2019

Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration.

Lucia A A Giannini, Sharon X Xie, Claire Peterson, Cecilia Zhou, Edward B Lee, David A Wolk, Murray Grossman, John Q Trojanowski, Corey T McMillan, David J Irwin

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Tau pathology associates with in vivo cortical thinning in Lewy body disorders.Annals of clinical and translational neurology · 2020
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lucia A A GianniniPenn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Sharon X XieDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Claire PetersonPenn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Cecilia ZhouPenn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Edward B LeeTranslational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
David A WolkAlzheimer's Disease Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Murray GrossmanPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
John Q TrojanowskiAlzheimer's Disease Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Corey T McMillanPenn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
David J IrwinPenn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
Project IV "Tackling Heterogeneity of Cognitive Trajectory in LBD"U19AG062418 · NIA · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2019 to 2023
$18.1M
Spreading Tau Pathology in Non-Amnestic Alzheimer's DiseaseR01AG054519 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jeffrey S Phillips · 2018 to 2026
$7.4M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
Age, Hearing Loss, and Sentence Comprehension: Neural CorrelatesR01AG038490 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GROSSMAN, MURRAY · 2012 to 2016
$2.1M
Efficient statistical methods for assessing dementia risk in Parkinson's diseaseR01NS102324 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI WEINTRAUB, DANIEL, XIE, SHARON XIANGWEN · 2017 to 2020
$1.3M
Identification of Endophenotypes in the Behavioral-Variant of Frontotemporal DemeK23NS088341 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2014 to 2018
$836k
Multimodal Biomarkers in Frontotemporal Lobar DegenerationK01AG043503 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MCMILLAN, COREY T · 2013 to 2017
$642k
NIA NIH HHS K01 AG043503NIA NIH HHS P01 AG017586NIA NIH HHS P30 AG010124NIA NIH HHS R01 AG038490NIA NIH HHS R01 AG054519NIA NIH HHS U01 AG052943NIA NIH HHS U19 AG062418NINDS NIH HHS K23 NS088341NINDS NIH HHS R01 NS102324
6 · The paper itself

Abstract

Digital pathology is increasingly prominent in neurodegenerative disease research, but variability in immunohistochemical staining intensity between staining batches prevents large-scale comparative studies. Here we provide a statistically rigorous method to account for staining batch effects in a large sample of brain tissue with frontotemporal lobar degeneration with tau inclusions (FTLD-Tau,

Indexed as

batch effectsdigital histopathologyfrontotemporal lobar degenerationlinear transformation methodpre-analytical variabilityvalidation of a method

Identifiers

PMID31333403
PMCPMC6616086

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.