SynthesisWorld journal of gastroenterology2019
Botulinum toxin injections after surgery for Hirschsprung disease: Systematic review and meta-analysis.
Synthesis in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Botulinum Toxin in Children and Adolescents-A Comprehensive Review of Clinical Applications.Toxins · 2026Review
- Surgical Complications in Hirschsprung Disease and the Impact of Botulinum Toxin Injection on Hirschsprung-Associated Enterocolitis.Journal of clinical medicine · 2026Article
- Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children.Journal of pediatric gastroenterology and nutrition · 2024Article
- Anorectal Manometry in Pediatric Colorectal Surgical Care.Children (Basel, Switzerland) · 2024Article
- Children with Hirschsprung disease exhibited alterations in host-microbial co-metabolism after pull-through operation.Pediatric surgery international · 2024Article
- A comparative observational study on intrasphincteric injections with Botulinum toxin vs. enteral neuromodulation in chronic refractory constipation.BMC pediatrics · 2023Observational
- State of the Art Bowel Management for Pediatric Colorectal Problems: Hirschsprung Disease.Children (Basel, Switzerland) · 2023Review
- Hirschsprung's disease associated enterocolitis: A comprehensive review.World journal of clinical pediatrics · 2023Review
- An Update of Pharmacological Management in Children with Functional Constipation.Paediatric drugs · 2023Review
- Risk factors for Hirschsprung-associated enterocolitis following Soave: a retrospective study over a decade.BMC pediatrics · 2022Article
- Treatment of postoperative intestinal dysfunction of hirschsprung's disease based on the principle of "anorectal balance".Frontiers in surgery · 2022Article
- High Anal Canal Pressure and Rectal Washouts Contribute to the Decrease of Anal Basal Pressure After Botulinum Toxin Injections in Paediatric Patients With Chronic Constipation.Frontiers in pediatrics · 2022Article
- Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child.Current gastroenterology reports · 2021Review
- The impact of botulinum injection for hospitalized children with Hirschsprung-associated enterocolitis.Pediatric surgery international · 2021Article
- Reoperative techniques and management in Hirschsprung disease: a narrative review.Translational gastroenterology and hepatology · 2021Review
- Inpatient management of Hirschsprung's associated enterocolitis treatment: the benefits of standardized care.Pediatric surgery international · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective surgery. Persistent obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis, a potential life-threatening condition. Important treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin injections.
aimTo give an overview of all empirical evidence on the effectiveness of botulinum toxin injections in patients with Hirschsprung disease.
methodsA systematic review and meta-analysis was done by searching PubMed, EMBASE and the Cochrane Library, using entry terms related to: (1) Hirschsprung disease; and (2) Botulinum toxin injections. 14 studies representing 278 patients met eligibility criteria. Data that were extracted were proportion of patients with improvement of obstructive symptoms or less enterocolitis after injection, proportion of patients with adverse effects and data on type botulinum toxin, mean dose, average age at first injection and patients with associated syndromes. Random-effects meta-analysis was used to aggregate effects and random-effects meta-regression was used to test for possible confounding factors.
resultsBotulinum toxin injections are effective in treating obstructive symptoms in on average 66% of patients [event rate (ER) = 0.66,
conclusionFindings from this systematic review and meta-analysis indicate that botulinum toxin injections are effective in treating obstructive symptoms and that adverse effects were present, but mild and temporary.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.