ArticleHuman brain mapping2019
Graph theory analysis of resting-state functional magnetic resonance imaging in essential tremor.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- The Contribution of Neuroimaging to the Understanding of Essential Tremor Pathophysiology: a Systematic Review.Cerebellum (London, England) · 2022Pooled it
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- Voxel-based morphometry and task functional magnetic resonance imaging in essential tremor: evidence for a disrupted brain network.Scientific reports · 2020Trial
- Functional network reorganization following VIM-MRgFUS for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Focussed ultrasound thalamotomy and functional MRI as windows to neural networks underlying essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Essential Tremor and Mortality in Older Adults: The Role of Word Recall, a Measure of Episodic Memory, in a 23-Year Follow-Up Study.Journal of clinical medicine · 2025Article
- Targeting the fundamentals for tremors: the frequency and amplitude coding in essential tremor.Journal of biomedical science · 2025Review
- Volumetric Assessment and Graph Theoretical Analysis of Thalamic Nuclei in Essential Tremor.Brain and behavior · 2025Article
- Thalamic and Visual Network Dysfunction Relates to Tremor Response in Thalamic Deep Brain Stimulation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Multilayer network analysis across cortical depths in 7-T resting-state fMRI.Network neuroscience (Cambridge, Mass.) · 2025Article
- Multilayer Network Analysis across Cortical Depths in Resting-State 7T fMRI.bioRxiv : the preprint server for biology · 2024Article
- The Role of Cerebellum and Basal Ganglia Functional Connectivity in Altered Voluntary Movement Execution in Essential Tremor.Cerebellum (London, England) · 2024Article
- Combined brain topological metrics with machine learning to distinguish essential tremor and tremor-dominant Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Macronutrient intake is associated with intelligence and neural development in adolescents.Frontiers in nutrition · 2024Article
- Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor.Neuroimage. Reports · 2023Article
- Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- [Essential tremor: are we just splitting hairs? Non-motor symptoms and essential tremor-plus].Revista de neurologia · 2023Review
- Identification of essential tremor based on resting-state functional connectivity.Human brain mapping · 2023Article
- Functional-structural large-scale brain networks are correlated with neurocognitive impairment in acute mild traumatic brain injury.Quantitative imaging in medicine and surgery · 2023Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Essential tremor (ET) is a neurological disease with both motor and nonmotor manifestations; however, little is known about its underlying brain basis. Furthermore, the overall organization of the brain network in ET remains largely unexplored. We investigated the topological properties of brain functional network, derived from resting-state functional magnetic resonance imaging (MRI) data, in 23 ET patients versus 23 healthy controls. Graph theory analysis was used to assess the functional network organization. At the global level, the functional network of ET patients was characterized by lower small-worldness values than healthy controls-less clustered functionality of the brain. At the regional level, compared with the healthy controls, ET patients showed significantly higher values of global efficiency, cost and degree, and a shorter average path length in the left inferior frontal gyrus (pars opercularis), right inferior temporal gyrus (posterior division and temporo-occipital part), right inferior lateral occipital cortex, left paracingulate, bilateral precuneus bilaterally, left lingual gyrus, right hippocampus, left amygdala, nucleus accumbens bilaterally, and left middle temporal gyrus (posterior part). In addition, ET patients showed significant higher local efficiency and clustering coefficient values in frontal medial cortex bilaterally, subcallosal cortex, posterior cingulate cortex, parahippocampal gyri bilaterally (posterior division), right lingual gyrus, right cerebellar flocculus, right postcentral gyrus, right inferior semilunar lobule of cerebellum and culmen of vermis. Finally, the right intracalcarine cortex and the left orbitofrontal cortex showed a shorter average path length in ET patients, while the left frontal operculum and the right planum polare showed a higher betweenness centrality in ET patients. In conclusion, the efficiency of the overall brain functional network in ET is disrupted. Further, our results support the concept that ET is a disorder that disrupts widespread brain regions, including those outside of the brain regions responsible for tremor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.