ArticleJournal of cardiac surgery2019
Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system.
Article in Journal of cardiac surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Machine Perfusion for Human Heart Preservation: A Systematic Review.Transplant international : official journal of the European Society for Organ Transplantation · 2022Pooled it
- Successful Heart Transplantation After 24 h of Ex-Situ Normothermic Perfusion Using ECMO Technology in an Animal Model: A Proof-of-Concept Study.Artificial organs · 2026Article
- Introduction of machine perfusion of donor hearts in a single center in Germany.International journal of cardiology. Heart & vasculature · 2023Article
- Graft preservation in heart transplantation: current approaches.Frontiers in cardiovascular medicine · 2023Review
- Successful Heart Transplantation After 7 h of Cold Storage and Paracorporeal Donor Heart Resuscitation.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Heart transplantation of patients with ventricular assist devices: impact of normothermic ex-vivo preservation using organ care system compared with cold storage.Journal of cardiothoracic surgery · 2020Article
- Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system.Journal of cardiac surgery · 2019Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesCold crystalloid cardioplegia for donor heart harvesting and cold ischemic storage conditions during the transportation is the standard of care during heart transplantation procedure. Organ care system (OCS) was introduced for more prolonged and reliable ex vivo organ management. This study evaluated the two different techniques used for myocardial preservation during the procurement and transportation of the heart using the OCS.
methodsWe performed prospective analysis of 43 patients with heart failure undergoing heart transplantation and using the OCS for donor organ transport. Donor hearts were arrested using blood cardioplegia and conditioning (n = 30) or standard Custodiol (SC) solution ( n = 13). Perfusion and cardiac function parameters were continuously monitored while the donor hearts were perfused in the OCS. Impact of preservation techniques on biochemical parameters and clinical outcomes were evaluated.
resultsAll donor hearts had stable perfusion and lactate characteristics in the OCS, with similar measures between the two groups at the beginning of the ex vivo perfusion. Ex vivo heart perfusion mean ending concentration of Interleukin (IL)-6 and IL-8 was significantly lower in the blood cardioplegia group compared to the standard care group. Clinical outcomes were comparable between the two groups of patients.
conclusionsThe use of blood cardioplegia and conditioning could be a safe method for myocardial protection in distant procurement and preservation of donor hearts in the OCS.
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Registered trials
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